{"id":"W4384627195","doi":"10.1172/jci171554","title":"The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic","funders":"National Institute of General Medical Sciences; Center for AIDS Research, University of Washington; National Institutes of Health; Center for AIDS Research, Johns Hopkins University; Philadelphia Foundation; Bill and Melinda Gates Foundation; Johns Hopkins University; Delaney AIDS Research Enterprise; NIH Office of the Director; U.S. Department of Energy; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Antiretroviral therapy; Viral replication; Biology; Virology; Human immunodeficiency virus (HIV); DNA replication; Viral load; DNA; Immunology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006532382,0.0001214896,0.0004867474,0.0002138747,0.0002015129,0.0007346565,0.0002494384,0.0004109171,0.001208861],"category_scores_gemma":[0.002953943,0.000234708,0.0001425626,0.0001884879,0.0002560887,0.0006408613,0.0002682065,0.0006584615,0.0002930877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694386,"about_ca_system_score_gemma":0.0002954916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005545188,"about_ca_topic_score_gemma":0.0004823401,"domain_scores_codex":[0.9995292,0.00008252035,0.00003888228,0.00007516673,0.0001606594,0.0001136744],"domain_scores_gemma":[0.998531,0.0003792094,0.0004495918,0.0001985113,0.000232831,0.0002088917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002102797,0.0005796311,0.5044433,0.0002006771,0.0001932176,0.00066373,0.0009724459,0.0006877737,0.3921999,0.0008455269,0.0009392732,0.09617171],"study_design_scores_gemma":[0.00008355077,0.003233928,0.9184856,0.00007911982,0.0002243513,0.004304023,0.0004720738,0.002667669,0.06496886,0.0006092268,0.004837891,0.00003378648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963084,0.001890358,0.0005322662,0.0001265243,0.00000948823,0.000008059501,0.0001381816,0.00002159292,0.0009651583],"genre_scores_gemma":[0.9988194,0.0002167666,0.0001904634,0.00005654534,0.00001706217,0.000008504881,0.000156494,0.000008007767,0.0005267297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001208861,"threshold_uncertainty_score":0.004044056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09817220153950623,"score_gpt":0.3869424013884001,"score_spread":0.2887701998488939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}