{"id":"W4384627195","doi":"10.1172/jci171554","title":"The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic","funders":"National Institute of General Medical Sciences; Center for AIDS Research, University of Washington; National Institutes of Health; Center for AIDS Research, Johns Hopkins University; Philadelphia Foundation; Bill and Melinda Gates Foundation; Johns Hopkins University; Delaney AIDS Research Enterprise; NIH Office of the Director; U.S. Department of Energy; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Antiretroviral therapy; Viral replication; Biology; Virology; Human immunodeficiency virus (HIV); DNA replication; Viral load; DNA; Immunology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003121061,0.00009860399,0.0003922904,0.0001737738,0.0001241804,0.00001424509,0.0002349392,0.0001983981,0.00003869056],"category_scores_gemma":[0.004350025,0.00004955754,0.0002575876,0.0003209114,0.0007360269,0.0001301214,0.00005209051,0.0004764157,0.00007117636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001880416,"about_ca_system_score_gemma":0.0003696863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008411241,"about_ca_topic_score_gemma":0.00002378735,"domain_scores_codex":[0.997411,0.0008256953,0.00128976,0.0001197756,0.0001456747,0.0002080632],"domain_scores_gemma":[0.9961811,0.002129108,0.0009825134,0.0002145988,0.000392953,0.00009977602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001242896,0.0002528659,0.8517627,0.0000217441,0.000605259,0.00001635101,0.0002611894,0.00004385199,0.1221414,0.0004238482,0.002995721,0.02023218],"study_design_scores_gemma":[0.003301677,0.002689658,0.7261478,0.0001095253,0.00004787423,0.00001778157,0.0000942373,0.00001697867,0.2619517,0.003332739,0.002222387,0.00006755184],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967915,0.0006344179,0.00001148242,0.001869581,0.000455858,0.0001474431,0.00002894619,0.00001192072,0.00004888754],"genre_scores_gemma":[0.9959825,0.003329635,0.00009052698,0.00008479736,0.00007932324,0.000004306526,0.00002588064,0.000008561678,0.0003944958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1398103,"threshold_uncertainty_score":0.5207701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09817220153950623,"score_gpt":0.3869424013884001,"score_spread":0.2887701998488939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}