{"id":"W4384627457","doi":"10.1084/jem.20230054","title":"TLR7/8 stress response drives histiocytosis in SLC29A3 disorders","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Institute of Medical Science, University of Tokyo; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Mochida Memorial Foundation for Medical and Pharmaceutical Research; University of Tokyo; Japan Agency for Medical Research and Development","keywords":"TLR7; Proinflammatory cytokine; Phagocyte; Monocyte; Biology; Immunology; Nucleoside; Inflammation; Toll-like receptor; Cell biology; Biochemistry; Phagocytosis; Innate immune system; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320868,0.0003681096,0.0002126875,0.0002370157,0.0002357048,0.0002091601,0.0001473829,0.0005090825,0.001985827],"category_scores_gemma":[0.0001372648,0.0001218858,0.0003311283,0.0001377513,0.0005080976,0.0001332657,0.0003096239,0.0004559541,0.0004038898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002945213,"about_ca_system_score_gemma":0.0002155425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005082168,"about_ca_topic_score_gemma":0.0008846999,"domain_scores_codex":[0.9998343,0.00003686592,0.00002410161,0.00003697125,0.00003957221,0.00002822922],"domain_scores_gemma":[0.9998738,0.00001818697,0.0000475415,0.000009581906,0.000009916019,0.00004103853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001784119,0.00002122082,0.001312512,0.00004161429,0.000008335678,0.001357633,0.00003334252,0.00004168976,0.995819,0.0001415124,0.00009045752,0.0009543259],"study_design_scores_gemma":[0.0001082751,0.0006734247,0.05908405,0.00005623908,0.0001080656,0.02685306,0.0004045796,0.002975038,0.9026451,0.0008784006,0.006185238,0.00002866107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964799,0.0005736054,0.001450172,0.0002207446,0.00002837303,0.00002458982,0.0003269563,0.00008241662,0.0008132348],"genre_scores_gemma":[0.9978065,0.0002608745,0.0009448973,0.0001477807,0.00001018006,0.00002502355,0.0001880123,0.00002332222,0.0005934786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985827,"threshold_uncertainty_score":0.006643236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202610218568044,"score_gpt":0.3540482745192791,"score_spread":0.3337872526624747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}