{"id":"W4384627457","doi":"10.1084/jem.20230054","title":"TLR7/8 stress response drives histiocytosis in SLC29A3 disorders","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Institute of Medical Science, University of Tokyo; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Mochida Memorial Foundation for Medical and Pharmaceutical Research; University of Tokyo; Japan Agency for Medical Research and Development","keywords":"TLR7; Proinflammatory cytokine; Phagocyte; Monocyte; Biology; Immunology; Nucleoside; Inflammation; Toll-like receptor; Cell biology; Biochemistry; Phagocytosis; Innate immune system; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057574,0.0001313027,0.0003265687,0.0002123087,0.00006399793,0.00000244892,0.0001727291,0.00005692275,0.0001999402],"category_scores_gemma":[0.0003032849,0.00007343229,0.00006107999,0.0004148246,0.0002630356,0.0000486456,0.00004653599,0.0003295779,0.000015642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634742,"about_ca_system_score_gemma":0.0001166164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000731403,"about_ca_topic_score_gemma":0.000006680003,"domain_scores_codex":[0.9985487,0.0001257755,0.000503335,0.00009558855,0.0004719462,0.0002546626],"domain_scores_gemma":[0.9990152,0.0003394333,0.0001889719,0.0001876598,0.00004533836,0.0002234627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01367792,0.0002730202,0.006107622,0.000105351,0.0000401387,0.0002816016,0.00453648,0.000004570445,0.963317,0.00001547038,0.008460457,0.003180362],"study_design_scores_gemma":[0.01054515,0.005425971,0.08733686,0.002208756,0.0001048953,0.0009315471,0.0425897,0.00009913605,0.8443017,0.0001628039,0.006085156,0.0002083099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770867,0.00632223,0.000005801237,0.01545377,0.0003522365,0.0001663521,0.000003732616,0.00001773422,0.0005915047],"genre_scores_gemma":[0.9973855,0.0008670911,0.00003452862,0.0006436105,0.0003901244,0.000004156805,0.000006735814,0.00001515471,0.0006531002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1190153,"threshold_uncertainty_score":0.2994482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202610218568044,"score_gpt":0.3540482745192791,"score_spread":0.3337872526624747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}