{"id":"W4384664474","doi":"10.1021/acsnano.3c01295","title":"Improvement of Gene Delivery by Minimal Bacteriophage Particles","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Ministry of Science and Technology, Taiwan; Academia Sinica","keywords":"Transduction (biophysics); Gene delivery; Biology; Bacteriophage; Genetic enhancement; Cell; Cell biology; Gene; Molecular biology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930017,0.00009329738,0.00009910687,0.00003714183,0.00003927563,0.00001056157,0.0001972805,0.00007063847,0.00004624114],"category_scores_gemma":[0.00002235256,0.00008958035,0.00005535927,0.0001429513,0.00006299788,0.000002631657,0.0001101,0.00003482833,0.00006635099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000886556,"about_ca_system_score_gemma":0.00005871485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001610699,"about_ca_topic_score_gemma":0.00002039367,"domain_scores_codex":[0.9991558,0.00003157816,0.000163008,0.0002225176,0.0001545773,0.0002725336],"domain_scores_gemma":[0.9995115,0.000009964032,0.00004412418,0.0003137437,0.00005808443,0.00006252232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004594392,0.00004888581,0.0003869557,0.00001128036,0.00004897394,0.000003370307,0.00002361992,0.000004854653,0.9792904,0.000001032191,0.00654335,0.01317782],"study_design_scores_gemma":[0.0004981299,0.001843072,0.0008647157,0.00000293466,0.000005670038,8.963301e-7,0.00002920839,0.00001331138,0.9916216,0.000008155218,0.00501956,0.00009277013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988671,0.0006545089,0.000009843648,0.0001315003,0.00004758835,0.0001274373,0.00007994005,0.00001517197,0.00006691954],"genre_scores_gemma":[0.998,0.0004178197,0.00007279641,0.0001459613,0.00006599791,0.00002792957,0.0001632503,0.00002044086,0.001085797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01308505,"threshold_uncertainty_score":0.365298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411326372509774,"score_gpt":0.2714672719546765,"score_spread":0.2573540082295787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}