{"id":"W4384664474","doi":"10.1021/acsnano.3c01295","title":"Improvement of Gene Delivery by Minimal Bacteriophage Particles","year":2023,"lang":"en","type":"article","venue":"ACS Nano","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Ministry of Science and Technology, Taiwan; Academia Sinica","keywords":"Transduction (biophysics); Gene delivery; Biology; Bacteriophage; Genetic enhancement; Cell; Cell biology; Gene; Molecular biology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003814006,0.000567617,0.000325524,0.0002433607,0.000142242,0.0004215779,0.0003153383,0.0003710499,0.0004620031],"category_scores_gemma":[0.0003565996,0.0002564956,0.0003458574,0.0001604656,0.000245163,0.0002580711,0.0002911515,0.0006745305,0.000261144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820826,"about_ca_system_score_gemma":0.0002837145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004035602,"about_ca_topic_score_gemma":0.0003550231,"domain_scores_codex":[0.9997124,0.00004873574,0.00003639398,0.00005835052,0.00009698658,0.00004707473],"domain_scores_gemma":[0.9998378,0.00003423036,0.00005271523,0.00001501801,0.00002855168,0.00003172516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003093275,0.00001606824,0.00006693879,0.00003144148,0.000003217179,0.0000215139,0.00001349576,0.0001094313,0.9987073,0.0001347195,0.00001222115,0.0008527015],"study_design_scores_gemma":[0.00001062814,0.0002154807,0.0004034609,0.000005040653,0.00001136282,0.00007053804,0.000006875879,0.0007743573,0.9966851,0.00004110573,0.001770574,0.000005512341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619598,0.001670454,0.03453058,0.0001158779,0.00006097363,0.00009710478,0.0001366333,0.0002086105,0.00121989],"genre_scores_gemma":[0.9674782,0.00115501,0.02856726,0.00005215859,0.00001470395,0.00009210388,0.0003723589,0.00009747258,0.002170687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000567617,"threshold_uncertainty_score":0.002772212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411326372509774,"score_gpt":0.2714672719546765,"score_spread":0.2573540082295787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}