{"id":"W4384664778","doi":"10.1038/s42004-023-00953-y","title":"Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography","year":2023,"lang":"en","type":"article","venue":"Communications Chemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Engineering and Physical Sciences Research Council; Research Councils UK; Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; Diamond Light Source; Wellcome Trust; Wellcome","keywords":"Intramolecular force; Tryptophan; Chemistry; Membrane protein; Stereochemistry; Membrane; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121458,0.0001454877,0.0001759195,0.00008071926,0.00006546192,0.00001507221,0.0005368961,0.0001929551,0.00001261572],"category_scores_gemma":[0.00009961959,0.0001589582,0.00006095834,0.0003484788,0.0003538361,0.000005190573,0.0005483686,0.0002376624,0.00000133687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001360228,"about_ca_system_score_gemma":0.00004288055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002588893,"about_ca_topic_score_gemma":0.00007948133,"domain_scores_codex":[0.9991351,0.00006600048,0.0002949309,0.0002719504,0.00005279131,0.0001792146],"domain_scores_gemma":[0.9987155,0.00001571622,0.0001362997,0.001013693,0.00007075621,0.00004805795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000050466,0.0001067133,0.0002230079,0.00005541707,0.00004163504,6.595674e-7,0.00006188029,0.000001297192,0.9964132,0.00002220603,0.0001492994,0.002874176],"study_design_scores_gemma":[0.000396356,0.00005226657,0.0003905307,0.00007208475,0.000009676781,0.000008455563,0.0002947703,0.00006512785,0.9841978,0.0001463962,0.01421356,0.0001530007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971819,0.0006960168,0.0001217567,0.0008814533,0.00001449449,0.0003507881,0.00009079224,0.00003027536,0.0006325275],"genre_scores_gemma":[0.9967137,0.001174334,0.001051437,0.00002056508,0.00001648818,0.0002235785,0.0005419175,0.00001988443,0.0002380721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01406427,"threshold_uncertainty_score":0.6482125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009985886616601157,"score_gpt":0.2557773505563981,"score_spread":0.2457914639397969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}