{"id":"W4384665022","doi":"10.1007/s00262-023-03486-4","title":"Oncolytic attenuated measles virus encoding NY-ESO-1 induces HLA I and II presentation of this tumor antigen by melanoma and dendritic cells","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Oncolytic virus; Measles virus; Antigen; CD8; Melanoma; Cancer research; Antigen presentation; Immune system; Biology; Tumor antigen; Cytotoxic T cell; Cell culture; T cell; Virology; Immunotherapy; Immunology; Measles; In vitro; Vaccination","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003153562,0.0002407027,0.000324064,0.0001692517,0.0002436842,0.00002994281,0.0002852322,0.0002076962,0.0001128029],"category_scores_gemma":[0.00003004225,0.0002403055,0.00006057474,0.0002779264,0.0004944101,0.00001700087,0.0001518097,0.000182587,0.000008433628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004039535,"about_ca_system_score_gemma":0.0001626628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003655779,"about_ca_topic_score_gemma":0.00009982185,"domain_scores_codex":[0.9983996,0.0002248335,0.0003334964,0.0004550117,0.000165996,0.0004211165],"domain_scores_gemma":[0.9992352,0.00006384215,0.0001625618,0.0003659267,0.0001210489,0.00005141134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001312649,0.00005358581,0.00142413,0.00002430756,0.0004550391,0.000004889888,0.0006163455,0.000008632051,0.9769976,0.000004493711,0.001015177,0.01808319],"study_design_scores_gemma":[0.001829657,0.002004177,0.003924064,0.00004008495,0.00001805172,0.00001383192,0.0003014664,0.00005066725,0.9851538,0.00003982818,0.006386484,0.0002379018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9391978,0.059734,0.00001595728,0.0002690665,0.00019587,0.0003744375,0.00009837388,0.00003318077,0.00008136107],"genre_scores_gemma":[0.9422301,0.05625857,0.00004528505,0.0002153601,0.00005175465,0.0001278502,0.0000891041,0.00005425222,0.0009276916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01784529,"threshold_uncertainty_score":0.9799376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083192203230009,"score_gpt":0.30938512561191,"score_spread":0.2885532035796098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}