{"id":"W4384665022","doi":"10.1007/s00262-023-03486-4","title":"Oncolytic attenuated measles virus encoding NY-ESO-1 induces HLA I and II presentation of this tumor antigen by melanoma and dendritic cells","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Oncolytic virus; Measles virus; Antigen; CD8; Melanoma; Cancer research; Antigen presentation; Immune system; Biology; Tumor antigen; Cytotoxic T cell; Cell culture; T cell; Virology; Immunotherapy; Immunology; Measles; In vitro; Vaccination","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080685,0.0002674846,0.0001905403,0.0001643413,0.0001504347,0.0003408039,0.0001343875,0.0002159826,0.001129483],"category_scores_gemma":[0.0001240947,0.000126285,0.0002440843,0.000111753,0.0001390671,0.00021985,0.0002208581,0.0007615438,0.0003788029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003208815,"about_ca_system_score_gemma":0.0001767465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004880088,"about_ca_topic_score_gemma":0.000513814,"domain_scores_codex":[0.9998492,0.00002091501,0.00001088217,0.00002561353,0.00002805896,0.00006543451],"domain_scores_gemma":[0.9998953,0.0000282794,0.00002093738,0.00001805299,0.00001175706,0.00002553632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171248,0.0000239613,0.0001690642,0.000007774683,0.000001940842,0.00002628915,0.00001441313,0.00004064547,0.9990317,0.0001094032,0.00001495761,0.0004428426],"study_design_scores_gemma":[0.00001908994,0.0002663665,0.002990819,0.000002969261,0.000009350027,0.0001384341,0.00004604668,0.0008288856,0.9943249,0.00007058043,0.001300529,0.000002092981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959971,0.0003738866,0.001584336,0.0000340451,0.0000357837,0.00002948674,0.000129913,0.00002709886,0.001788476],"genre_scores_gemma":[0.9966438,0.0001480618,0.0006173464,0.00002251668,0.000008243838,0.00001573761,0.0001860836,0.00001206631,0.00234626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129483,"threshold_uncertainty_score":0.003778458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083192203230009,"score_gpt":0.30938512561191,"score_spread":0.2885532035796098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}