{"id":"W4384695089","doi":"10.22215/etd/2023-15633","title":"The Role of Brain Derived Neurotrophic Factor (BDNF) in Regulating α-synuclein Pathology in Primary Microglia and Neurons.","year":2023,"lang":"en","type":"dissertation","venue":"","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Microglia; Neurotrophic factors; Neuroprotection; Brain-derived neurotrophic factor; Neurotrophin; Neuroscience; Neuron; Inflammation; Medicine; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370458,0.0002013755,0.0001044284,0.0001740436,0.0001952289,0.0002743076,0.0001022122,0.0002842891,0.0009975262],"category_scores_gemma":[0.00008260012,0.0000668604,0.000214841,0.00009092318,0.0001550438,0.0001612469,0.0001052446,0.0003166391,0.0003622617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795605,"about_ca_system_score_gemma":0.0003862359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001529678,"about_ca_topic_score_gemma":0.003041322,"domain_scores_codex":[0.9999506,0.000005951684,0.000002537603,0.000008004889,0.00001750223,0.00001540603],"domain_scores_gemma":[0.9999642,0.000004620565,0.000006319081,0.000001438294,0.000009821368,0.00001362372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003260393,0.0001244865,0.0009460388,0.0006846729,0.00001524335,0.0006702268,0.0001304863,0.0001849127,0.9017912,0.001145357,0.001401904,0.09257931],"study_design_scores_gemma":[0.00007756241,0.002084702,0.09571515,0.0006791292,0.0001537603,0.00520412,0.0004136372,0.0008248889,0.792133,0.003712493,0.09897333,0.00002826431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5780216,0.3699493,0.006903568,0.003444561,0.0005717525,0.0001373006,0.0009795615,0.0001151154,0.03987715],"genre_scores_gemma":[0.8052881,0.1525157,0.005760361,0.000433136,0.0001427355,0.00008353577,0.0004829187,0.00001898555,0.03527451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529678,"threshold_uncertainty_score":0.003337026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670373408364322,"score_gpt":0.2579391323983058,"score_spread":0.2412353983146626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}