{"id":"W4384695354","doi":"10.3390/cells12141878","title":"Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Genome Canada","keywords":"Innate immune system; Neuroinflammation; Microglia; Biology; Scrapie; Immune system; Gliosis; Hamster; Immunology; Cell biology; Inflammation; Neuroscience; Pathology; Molecular biology; Medicine; Disease; Prion protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012601,0.00005512935,0.00008191868,0.00006962845,0.00001237263,0.000004437034,0.00003882742,0.00006175869,0.00001281197],"category_scores_gemma":[0.00003676465,0.00005565748,0.00004288383,0.0001749857,0.0000223978,0.000004324553,0.00004964421,0.00003229389,0.000004965333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008885868,"about_ca_system_score_gemma":0.00003495799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003488327,"about_ca_topic_score_gemma":0.00001432491,"domain_scores_codex":[0.9994735,0.00003361668,0.0001817558,0.0001150536,0.0000662852,0.0001298451],"domain_scores_gemma":[0.9996868,0.000004556495,0.0001022718,0.0001333222,0.00004721576,0.0000258063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004987619,0.00002462895,0.02606295,0.00009794671,0.000008652236,5.926066e-7,0.00005875869,0.001184523,0.9651649,0.00001971809,0.00001331512,0.007314117],"study_design_scores_gemma":[0.0002324089,0.0001059349,0.1631084,0.00002501172,0.000002892984,6.035788e-8,0.00001099728,0.0004143761,0.8349933,0.0000542097,0.001002834,0.00004952952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986902,0.0008288912,0.0001469063,0.000005954979,0.00006423111,0.0001814595,0.00002033474,0.00000764981,0.0000543127],"genre_scores_gemma":[0.9967656,0.00286683,0.0000556898,0.000003220458,0.00001449647,0.000008551733,0.00006506896,0.000008055822,0.0002125071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1370455,"threshold_uncertainty_score":0.2269646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009109454430140499,"score_gpt":0.2482568234802543,"score_spread":0.2391473690501138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}