{"id":"W4384695354","doi":"10.3390/cells12141878","title":"Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Genome Canada","keywords":"Innate immune system; Neuroinflammation; Microglia; Biology; Scrapie; Immune system; Gliosis; Hamster; Immunology; Cell biology; Inflammation; Neuroscience; Pathology; Molecular biology; Medicine; Disease; Prion protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187712,0.0002309258,0.0001939667,0.0001062854,0.000100773,0.0002039465,0.00006366076,0.0002256268,0.0005881431],"category_scores_gemma":[0.0001229845,0.00005763912,0.000112325,0.00005677381,0.0002059675,0.0001691594,0.0001350403,0.000321611,0.0001361996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009393696,"about_ca_system_score_gemma":0.00009768829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001192235,"about_ca_topic_score_gemma":0.0002337738,"domain_scores_codex":[0.9999157,0.00002145919,0.000009354444,0.00001665493,0.000009478804,0.0000273502],"domain_scores_gemma":[0.9999316,0.000008126389,0.00002064861,0.000005555378,0.00001310132,0.00002106495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004178642,0.00005829188,0.001352306,0.00006024347,0.000005058218,0.0001146182,0.00006048595,0.00002607921,0.9963465,0.00004605374,0.00002521071,0.001487255],"study_design_scores_gemma":[0.00008290049,0.003106051,0.1831216,0.0000868065,0.00009083459,0.001069674,0.0007061493,0.001331223,0.807282,0.0005581178,0.002544706,0.00002002336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979924,0.001235139,0.0002535913,0.00003245467,0.00001167661,0.00000800251,0.00004603616,0.000009345325,0.0004113043],"genre_scores_gemma":[0.9984475,0.0007576821,0.0002580028,0.00003398793,0.000007628406,0.00001727713,0.0000502058,0.000001797116,0.0004258328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005881431,"threshold_uncertainty_score":0.001967549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009109454430140499,"score_gpt":0.2482568234802543,"score_spread":0.2391473690501138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}