{"id":"W4384695361","doi":"10.22215/etd/2023-15485","title":"Sex Differences in the Antidepressant Effects of Ketamine","year":2023,"lang":"en","type":"dissertation","venue":"","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Ketamine; Antidepressant; Mechanism (biology); Mechanism of action; Major depressive disorder; Suicidal ideation; Psychology; Antagonist; NMDA receptor; Mood disorders; Mood; Clinical psychology; Medicine; Psychiatry; Internal medicine; Anxiety; Poison control; Human factors and ergonomics; Receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183894,0.0001735542,0.0002093506,0.0002021204,0.0001145783,0.0002496256,0.00008902497,0.0001881995,0.003985767],"category_scores_gemma":[0.0002271137,0.0001052187,0.000150014,0.00009377317,0.0001266866,0.0002049752,0.0001314275,0.0003929143,0.0005877925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001194611,"about_ca_system_score_gemma":0.0001285041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000260922,"about_ca_topic_score_gemma":0.0004572096,"domain_scores_codex":[0.9999173,0.00001014997,0.000006107373,0.0000210231,0.00002057295,0.00002487804],"domain_scores_gemma":[0.9998934,0.00001455426,0.00002941963,0.000009544528,0.0000168723,0.00003615021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01315094,0.001515393,0.01995723,0.0002971821,0.0001290559,0.000717557,0.0005112181,0.00007023677,0.8818779,0.001251791,0.001736658,0.07878468],"study_design_scores_gemma":[0.0005558553,0.01654343,0.7131525,0.0001708672,0.0003501581,0.002766101,0.001162203,0.000465532,0.2422014,0.001258789,0.02129874,0.00007438936],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902105,0.00276283,0.000485273,0.0002337186,0.0001123318,0.00003716144,0.0008543045,0.0000237623,0.005279991],"genre_scores_gemma":[0.9824424,0.003410498,0.0006664437,0.0004035564,0.00005135436,0.0001146007,0.0007290284,0.00002711419,0.01215516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003985767,"threshold_uncertainty_score":0.01333368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180569949183756,"score_gpt":0.297417096242498,"score_spread":0.2793601013241224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}