{"id":"W4384696308","doi":"10.1101/2023.07.17.549300","title":"EHMT2/G9a-Inhibition Reprograms Cancer-Associated Fibroblasts (CAFs) to a More Differentiated, Less Proliferative and Invasive State","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Hospital for Sick Children; Princess Margaret Cancer Centre; Ted Rogers Centre for Heart Research; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; McGill University; Genentech; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Epigenetics; Stromal cell; Extracellular matrix; Biology; Cancer-Associated Fibroblasts; Cancer research; Cell biology; Tumor microenvironment; Cancer cell; Cancer; Tumor progression; Genetics; Tumor cells","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166239,0.0003261835,0.0002902757,0.0002033851,0.0001429571,0.0002330541,0.0001543279,0.0002568548,0.00165993],"category_scores_gemma":[0.00008084805,0.000105929,0.0003027493,0.0001780961,0.0001813909,0.0001241442,0.0001577676,0.0005854406,0.0003910746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001996625,"about_ca_system_score_gemma":0.0001425285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007301307,"about_ca_topic_score_gemma":0.00119288,"domain_scores_codex":[0.999843,0.00002048882,0.00001421095,0.00003587997,0.00005178042,0.00003465906],"domain_scores_gemma":[0.9999254,0.00001256059,0.00001871388,0.00001127996,0.00001015428,0.00002188289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000662878,0.00001882984,0.00009472551,0.00001533866,0.000003259624,0.00002300537,0.000003683831,0.00002817342,0.9992995,0.00002028949,0.000033221,0.0003937344],"study_design_scores_gemma":[0.000009957883,0.0001707122,0.00181425,0.000001740935,0.000007264252,0.00007979411,0.00001117866,0.000468529,0.9960986,0.00001391767,0.001321803,0.000002250444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914819,0.001118566,0.003796659,0.0001631948,0.000066669,0.00005291383,0.001304848,0.0002876846,0.00172759],"genre_scores_gemma":[0.9914688,0.0005252137,0.00242597,0.00008447209,0.00001034213,0.00004447606,0.001170225,0.00004363362,0.004226842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00165993,"threshold_uncertainty_score":0.005553007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182717585601719,"score_gpt":0.256713922071596,"score_spread":0.2348867462155789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}