{"id":"W4384819222","doi":"10.1007/s40121-023-00830-0","title":"Assessment of Drug–Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using Physiologically Based Pharmacokinetic Modeling and Simulations","year":2023,"lang":"en","type":"article","venue":"Infectious Diseases and Therapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; Simon Fraser University","funders":"AbbVie","keywords":"Physiologically based pharmacokinetic modelling; Fentanyl; Pharmacokinetics; Pharmacology; Medicine; CYP3A4; Drug; Population; Hepatitis C; Drug interaction; Internal medicine; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008328159,0.0008771904,0.0008832327,0.0006186008,0.0003969358,0.000857069,0.0007052012,0.001436171,0.00151453],"category_scores_gemma":[0.002542396,0.0005100637,0.001670031,0.0003523634,0.0002981588,0.0004460595,0.000542092,0.0008976189,0.0001666936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001013532,"about_ca_system_score_gemma":0.001674732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02289831,"about_ca_topic_score_gemma":0.007561899,"domain_scores_codex":[0.9997343,0.0001131916,0.00001869127,0.00003991334,0.00005275926,0.00004108108],"domain_scores_gemma":[0.9975051,0.001981156,0.0002442029,0.00003437338,0.0001646169,0.00007057239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00007455805,0.00004500323,0.002882592,0.00003436089,0.0000531201,0.00008571755,0.00001153567,0.9947643,0.0003212859,0.0002669207,0.0001150311,0.001345499],"study_design_scores_gemma":[0.00001766427,0.00006522458,0.0005348249,0.000006565134,0.00002742185,0.0000271285,0.000008630282,0.9987298,0.0002090386,0.0002186952,0.0001486757,0.00000631329],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.908282,0.00204211,0.07954691,0.0009119668,0.00007567925,0.0002374322,0.0010763,0.0002600501,0.007567543],"genre_scores_gemma":[0.9901466,0.0004298096,0.007606587,0.00008885506,0.00001759549,0.0001488115,0.0003481618,0.00001758744,0.001196082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02289831,"threshold_uncertainty_score":0.04553008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02749478866268015,"score_gpt":0.3512274939414294,"score_spread":0.3237327052787492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}