{"id":"W4384819222","doi":"10.1007/s40121-023-00830-0","title":"Assessment of Drug–Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using Physiologically Based Pharmacokinetic Modeling and Simulations","year":2023,"lang":"en","type":"article","venue":"Infectious Diseases and Therapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; Simon Fraser University","funders":"AbbVie","keywords":"Physiologically based pharmacokinetic modelling; Fentanyl; Pharmacokinetics; Pharmacology; Medicine; CYP3A4; Drug; Population; Hepatitis C; Drug interaction; Internal medicine; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002208924,0.0001251181,0.0002758698,0.0002015114,0.0001606941,0.00004079022,0.00003377719,0.00003031569,0.00002056827],"category_scores_gemma":[0.00007092753,0.00009180304,0.0000447378,0.0002800584,0.0001228598,0.0001184459,0.00004122403,0.0001719991,4.100935e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007109603,"about_ca_system_score_gemma":0.00004376049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001767675,"about_ca_topic_score_gemma":0.00005303087,"domain_scores_codex":[0.9987708,0.0003542729,0.000277802,0.0002186429,0.0002240944,0.0001544103],"domain_scores_gemma":[0.9991636,0.0004168192,0.0001176362,0.0001123398,0.0001043247,0.00008531944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001328876,0.0002534872,0.9473215,0.00005949208,0.00007966823,0.000001754977,0.0002334516,0.006283553,0.0003339009,0.0000193187,0.000004082405,0.0452769],"study_design_scores_gemma":[0.004571365,0.0001554166,0.5453286,0.00006945618,0.00005767482,3.546614e-7,0.0000220635,0.4490974,0.00002331909,0.000610472,0.000009759078,0.00005418797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998073,0.0004144218,0.0002959021,0.0001132191,0.00003932138,0.0009042847,0.00008762851,0.00003563034,0.00003656479],"genre_scores_gemma":[0.991774,0.007936917,0.00002490669,0.00007590446,0.00003513667,0.00003837818,0.00009668019,0.00001563325,0.000002411353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4428138,"threshold_uncertainty_score":0.3743619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02749478866268015,"score_gpt":0.3512274939414294,"score_spread":0.3237327052787492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}