{"id":"W4384820531","doi":"10.1158/2159-8290.cd-23-0225","title":"The Transcriptional and Epigenetic Landscape of Cancer Cell Lineage Plasticity","year":2023,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cancer Council NSW; Cancer Council South Australia; Canadian Institutes of Health Research; Flinders Foundation; Canadian HIV Trials Network, Canadian Institutes of Health Research; Terry Fox Foundation; U.S. Department of Defense; Australian Government; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation","keywords":"Epigenetics; Biology; Lineage (genetic); Cancer; Phenotypic plasticity; Metastasis; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003101397,0.0004136307,0.000608318,0.0008966466,0.0002005124,0.000657009,0.0004726118,0.0006749446,0.001904804],"category_scores_gemma":[0.0003262818,0.0001672789,0.0002426133,0.0008901687,0.0004363215,0.0007633184,0.0004627767,0.001220465,0.001082669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005844794,"about_ca_system_score_gemma":0.0008156636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006884086,"about_ca_topic_score_gemma":0.001620783,"domain_scores_codex":[0.9999079,0.00001926045,0.0000106388,0.00001602459,0.00003449194,0.00001185568],"domain_scores_gemma":[0.9998695,0.00006014353,0.00001648183,0.000004584452,0.00003723046,0.00001213401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006595362,0.00003344624,0.0002519103,0.01249296,0.00006398959,0.0003403875,0.0001021948,0.0005762298,0.0150937,0.01239559,0.02306183,0.9355218],"study_design_scores_gemma":[0.000006618169,0.00006363621,0.0008091026,0.001195086,0.0000444602,0.001424445,0.00005762457,0.0001168431,0.002934175,0.003096404,0.9902355,0.00001616626],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000284788,0.99694,0.0003153016,0.0004799413,0.0002163427,0.000003912337,0.00002312204,0.000008940615,0.00172766],"genre_scores_gemma":[0.001698185,0.9966753,0.0002784809,0.0002134751,0.0001373704,0.000005726773,0.0000362748,0.000001853935,0.0009534142],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001904804,"threshold_uncertainty_score":0.006372213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03571909190268062,"score_gpt":0.3326699096117385,"score_spread":0.2969508177090579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}