{"id":"W4384820531","doi":"10.1158/2159-8290.cd-23-0225","title":"The Transcriptional and Epigenetic Landscape of Cancer Cell Lineage Plasticity","year":2023,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cancer Council NSW; Cancer Council South Australia; Canadian Institutes of Health Research; Flinders Foundation; Canadian HIV Trials Network, Canadian Institutes of Health Research; Terry Fox Foundation; U.S. Department of Defense; Australian Government; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation","keywords":"Epigenetics; Biology; Lineage (genetic); Cancer; Phenotypic plasticity; Metastasis; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235248,0.0002374479,0.000449308,0.00002464531,0.00009365675,0.00004559696,0.0001876153,0.0002237835,0.0000180237],"category_scores_gemma":[0.00002309127,0.0001621295,0.0002254702,0.00008540831,0.000111639,0.000004074239,0.00007857863,0.0001126351,0.000002056048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002372211,"about_ca_system_score_gemma":0.0003872414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001147199,"about_ca_topic_score_gemma":0.0006508335,"domain_scores_codex":[0.9988501,0.00007154189,0.000384069,0.000351062,0.000143281,0.0001999633],"domain_scores_gemma":[0.99935,0.00009083992,0.000241831,0.0002122033,0.0000517606,0.00005339419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000125966,0.0001226798,0.001189489,0.02682481,0.001297757,0.000004000465,0.0001005711,0.0007445273,0.01881256,0.0002600803,0.001462885,0.9490547],"study_design_scores_gemma":[0.0002015982,0.00007721567,0.0004726644,0.001265328,0.0005006305,3.997275e-7,0.00001762949,0.00001920948,0.004480454,0.00002859373,0.9926653,0.0002709822],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004156797,0.9939129,0.0002334352,0.000008820836,0.0004283873,0.0002919207,0.0008083184,0.000004950571,0.0001545079],"genre_scores_gemma":[0.001487797,0.9955993,0.00001331965,0.000009268627,0.0005180311,0.0002033038,0.0001839051,0.00004855343,0.001936549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9912024,"threshold_uncertainty_score":0.661145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03571909190268062,"score_gpt":0.3326699096117385,"score_spread":0.2969508177090579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}