{"id":"W4384830870","doi":"10.1016/j.virol.2023.07.009","title":"Protease-deleted adenovirus as an alternative for replication-competent adenovirus vector","year":2023,"lang":"en","type":"article","venue":"Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Biology; Transgene; Genetic enhancement; Virology; Gene; Adenoviridae; Vector (molecular biology); Molecular biology; HeLa; Viral vector; Cell culture; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005368731,0.0002177225,0.0002257728,0.0001637288,0.0001703413,0.00002548812,0.0005427474,0.0002476284,0.0001212188],"category_scores_gemma":[0.0003034002,0.0002175592,0.0001177087,0.0002517939,0.0001634945,0.000006828789,0.0001473378,0.0001573807,0.0004471107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003466952,"about_ca_system_score_gemma":0.0001833872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006980924,"about_ca_topic_score_gemma":0.000138494,"domain_scores_codex":[0.9978151,0.0002360639,0.0002729819,0.0009001177,0.0002022764,0.0005735071],"domain_scores_gemma":[0.998386,0.00005505722,0.0001118591,0.001092336,0.0001753849,0.0001794205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003611218,0.0001113953,0.00013124,0.00001338238,0.0001244242,0.00001704383,0.00007345819,0.0001716877,0.988413,0.0003439391,0.001767387,0.005221783],"study_design_scores_gemma":[0.00187258,0.01168768,0.002811826,0.000004284962,0.00002135349,0.0000399438,0.00005223515,0.001624916,0.9267049,0.001447491,0.05337919,0.0003536387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960454,0.0002546861,0.0005472929,0.001272173,0.0001679955,0.001270908,0.0001331674,0.0001073336,0.0002010283],"genre_scores_gemma":[0.9941724,0.0001262902,0.0002847083,0.001308078,0.0006422974,0.00132219,0.0007520029,0.00008362691,0.001308442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06170819,"threshold_uncertainty_score":0.8871806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0366939436556671,"score_gpt":0.345025728024022,"score_spread":0.308331784368355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}