{"id":"W4384922902","doi":"10.1038/s41467-023-40088-1","title":"C. elegans ageing is accelerated by a self-destructive reproductive programme","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; National Institutes of Health; University of Toronto; Rowan University; Francis Crick Institute; Wellcome Trust; Wellcome","keywords":"Ageing; Caenorhabditis elegans; Biology; Computational biology; Gerontology; Medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002639,0.0002142423,0.0001729544,0.0002365976,0.0001711898,0.0001921163,0.0001315342,0.0001860032,0.0008767106],"category_scores_gemma":[0.000140551,0.0001092287,0.0001795129,0.00008003632,0.0001624209,0.0001310649,0.0002664296,0.0003552098,0.0002596905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483398,"about_ca_system_score_gemma":0.0001447595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006665651,"about_ca_topic_score_gemma":0.001323459,"domain_scores_codex":[0.9999176,0.000006580996,0.000009566712,0.00002325568,0.00002746861,0.00001552529],"domain_scores_gemma":[0.9998164,0.00001924257,0.00006196832,0.00002726488,0.00002235008,0.00005276093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006246354,0.00001862079,0.0005967647,0.00002982526,0.00000398611,0.00006925534,0.00001212606,0.00005230659,0.9977052,0.00007160026,0.00006439106,0.001313476],"study_design_scores_gemma":[0.00004181754,0.0008311408,0.1185872,0.0000598485,0.00003525147,0.001495287,0.00006699596,0.002941756,0.8691736,0.0002924753,0.006440029,0.00003450452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958578,0.0005122597,0.001532757,0.00006196077,0.00002730204,0.00001417043,0.0003511709,0.0001820598,0.001460532],"genre_scores_gemma":[0.9950696,0.0004296513,0.001803535,0.00006605973,0.000007537516,0.00002885171,0.0002714906,0.0000308381,0.002292323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008767106,"threshold_uncertainty_score":0.002932966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392169383381836,"score_gpt":0.29799608954421,"score_spread":0.2740743957103917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}