{"id":"W4384923460","doi":"10.1158/1078-0432.ccr-23-0757","title":"Molecular Residual Disease in Breast Cancer: Detection and Therapeutic Interception","year":2023,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Breast cancer; Oncology; Disease; Clinical trial; Internal medicine; Minimal residual disease; Cancer; Immunotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001497475,0.00027932,0.0007100932,0.000231326,0.00008445216,0.00007760613,0.0003383855,0.0004813518,0.00003597288],"category_scores_gemma":[0.0003321361,0.0002537248,0.0002701031,0.0004247699,0.0003320431,0.000002718291,0.0005025266,0.0009068949,0.00002837811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000210281,"about_ca_system_score_gemma":0.001192535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000909379,"about_ca_topic_score_gemma":0.001985617,"domain_scores_codex":[0.9968687,0.0007078464,0.0007013083,0.0009218637,0.0003123059,0.0004879626],"domain_scores_gemma":[0.9985829,0.0003013955,0.0001390662,0.0005150365,0.0001698822,0.000291747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002502868,0.00006346421,0.0007504187,0.002468463,0.0001270912,0.00003016145,0.000007790676,0.00002092238,0.0001087978,0.00001592984,0.0005156149,0.9956411],"study_design_scores_gemma":[0.0007590919,0.0002907017,0.005632314,0.005504057,0.0002924956,0.000007427215,0.00002271809,0.00007053364,0.00002891646,0.0002955391,0.9865389,0.0005572733],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01602953,0.9818694,0.0000123874,0.0003239737,0.0004387228,0.0008145912,0.0004756599,0.00001326004,0.00002248082],"genre_scores_gemma":[0.01002697,0.9873061,0.000003186607,0.0001138925,0.00124651,0.0009320235,0.000101489,0.00009785891,0.0001719884],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9950838,"threshold_uncertainty_score":0.9999915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2059661286484782,"score_gpt":0.5311124960904527,"score_spread":0.3251463674419746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}