{"id":"W4384924729","doi":"10.1016/j.chom.2023.06.013","title":"Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of Illinois at Chicago; National Institutes of Health; University of Illinois at Urbana-Champaign; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; University of Alberta; California Department of Fish and Game; Cleveland Clinic; University of Chicago","keywords":"Biology; NS3; Virology; Helicase; Dengue virus; Viral replication; Acetylation; RNA Helicase A; Flavivirus; Dengue fever; Polymerase; Zika virus; Virus; RNA; Genetics; Hepatitis C virus; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217136,0.0004097176,0.0002764519,0.0001802475,0.0005653215,0.0005762167,0.0002589081,0.0003548317,0.002748878],"category_scores_gemma":[0.0003194402,0.0003137121,0.0005581899,0.0001124776,0.0003727157,0.0004215086,0.0004833473,0.0005624713,0.001104832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008342298,"about_ca_system_score_gemma":0.0005041942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002997596,"about_ca_topic_score_gemma":0.004126457,"domain_scores_codex":[0.9997638,0.00003461898,0.00002726389,0.00005229768,0.00005185577,0.00007010836],"domain_scores_gemma":[0.9998135,0.00001845443,0.00005253197,0.0000279494,0.00003756809,0.00004998883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003887769,0.00001647278,0.00283232,0.00007354451,0.000023321,0.0001456544,0.00004213036,0.000140254,0.993006,0.0004229164,0.0004204717,0.00248818],"study_design_scores_gemma":[0.00003095834,0.0001643576,0.0655501,0.00002461322,0.00003350627,0.0006241624,0.0001920079,0.002497444,0.9228998,0.0005496742,0.007409483,0.00002396308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887326,0.003260276,0.003688473,0.000320368,0.000131583,0.00002043628,0.0007550585,0.000225681,0.002865573],"genre_scores_gemma":[0.997075,0.0002598646,0.0006744291,0.00005209877,0.000006647789,0.000004695606,0.0005783463,0.00002120572,0.001327712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002997596,"threshold_uncertainty_score":0.009195924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008483475819440521,"score_gpt":0.2777259643482033,"score_spread":0.2692424885287628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}