{"id":"W4384924729","doi":"10.1016/j.chom.2023.06.013","title":"Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of Illinois at Chicago; National Institutes of Health; University of Illinois at Urbana-Champaign; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; University of Alberta; California Department of Fish and Game; Cleveland Clinic; University of Chicago","keywords":"Biology; NS3; Virology; Helicase; Dengue virus; Viral replication; Acetylation; RNA Helicase A; Flavivirus; Dengue fever; Polymerase; Zika virus; Virus; RNA; Genetics; Hepatitis C virus; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288878,0.0001004712,0.0001630237,0.00003661578,0.00008654609,0.0000134119,0.0001162444,0.00007058154,0.0001254736],"category_scores_gemma":[0.00005194598,0.00007753917,0.0001953192,0.0002309189,0.00004043596,0.00003290392,0.00004744208,0.00006178826,0.00007953894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002466963,"about_ca_system_score_gemma":0.00006007557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005567511,"about_ca_topic_score_gemma":0.000004507232,"domain_scores_codex":[0.9991791,0.00001901715,0.0002276453,0.0002880583,0.0001060361,0.0001801026],"domain_scores_gemma":[0.9989918,0.00004286858,0.0001343262,0.0006549366,0.0001125492,0.00006344818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000225693,0.00009308376,0.0004103328,0.0001241022,0.00001980153,6.821218e-7,0.0001562826,0.000001407494,0.8738558,0.00003475049,0.122576,0.00250205],"study_design_scores_gemma":[0.001761378,0.000121807,0.003519497,0.00004372684,0.0002260762,0.000002621849,0.0001065957,0.0009174193,0.8914953,0.00004671389,0.1016656,0.00009332925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928795,0.001022262,0.0005816945,0.003526709,0.0001736588,0.001047072,0.0003257986,0.00005691085,0.0003864394],"genre_scores_gemma":[0.9911004,0.0001023131,0.00004481404,0.001039404,0.0001578112,0.00008547551,0.0002703128,0.00002553673,0.007173961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0209104,"threshold_uncertainty_score":0.3161956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008483475819440521,"score_gpt":0.2777259643482033,"score_spread":0.2692424885287628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}