{"id":"W4384926072","doi":"10.1001/jamanetworkopen.2023.24963","title":"Prevalence of Low-Frequency, Antiviral Resistance Variants in SARS-CoV-2 Isolates in Ontario, Canada, 2020-2023","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; St. Michael's Hospital; Toronto General Hospital; University of Toronto; Ontario Institute for Cancer Research; York University; Hospital for Sick Children; Kingston Health Sciences Centre; Queen's University","funders":"Government of Canada; Canadian Institutes of Health Research; Government of Ontario; Ontario Genomics; Genome Canada","keywords":"Ritonavir; Virology; Asymptomatic; Viral load; Cohort; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Drug resistance; Deep sequencing; Virus; Biology; Coronavirus disease 2019 (COVID-19); Internal medicine; Genome; Gene; Genetics; Infectious disease (medical specialty); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003459301,0.000319091,0.0003555827,0.0009019691,0.002154189,0.0008865585,0.0008026337,0.0003548001,0.001542848],"category_scores_gemma":[0.001268783,0.0003768555,0.0002850969,0.001684535,0.0006195097,0.000284281,0.0004855673,0.0003923844,0.00021159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01003537,"about_ca_system_score_gemma":0.01296142,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9696469,"about_ca_topic_score_gemma":0.9845672,"domain_scores_codex":[0.9994346,0.00002167353,0.00003266004,0.00012657,0.000231857,0.0001526281],"domain_scores_gemma":[0.9985315,0.00005266112,0.0003794053,0.00005738618,0.0007054865,0.0002736405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004724894,0.000009518883,0.9976147,0.00001352505,0.00001293758,0.000102116,0.0002675921,0.00003073793,0.0005922921,0.00001686854,0.0002981905,0.0009943229],"study_design_scores_gemma":[0.000003619745,0.00001505199,0.9989659,0.000008458757,0.000006680186,0.0001062307,0.0004000905,0.00009087405,0.00007592356,0.000005522131,0.0003181853,0.000003482313],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958349,0.0001714105,0.00006787629,0.00007770212,0.000004294081,0.00002794122,0.002938297,0.000006979426,0.000870535],"genre_scores_gemma":[0.9971898,0.0001483206,0.000115527,0.00006895437,0.000003836112,0.00001590258,0.001816242,0.000005010792,0.0006363707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03035313,"threshold_uncertainty_score":0.07281202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03529592364362828,"score_gpt":0.3196789620739154,"score_spread":0.2843830384302872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}