{"id":"W4384926072","doi":"10.1001/jamanetworkopen.2023.24963","title":"Prevalence of Low-Frequency, Antiviral Resistance Variants in SARS-CoV-2 Isolates in Ontario, Canada, 2020-2023","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; St. Michael's Hospital; Toronto General Hospital; University of Toronto; Ontario Institute for Cancer Research; York University; Hospital for Sick Children; Kingston Health Sciences Centre; Queen's University","funders":"Government of Canada; Canadian Institutes of Health Research; Government of Ontario; Ontario Genomics; Genome Canada","keywords":"Ritonavir; Virology; Asymptomatic; Viral load; Cohort; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Drug resistance; Deep sequencing; Virus; Biology; Coronavirus disease 2019 (COVID-19); Internal medicine; Genome; Gene; Genetics; Infectious disease (medical specialty); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001711275,0.00023522,0.0006152309,0.0001761794,0.00007208274,0.00007577281,0.0009273053,0.0001808749,0.0000601906],"category_scores_gemma":[0.0003453542,0.0002303173,0.00006183737,0.002006183,0.00009377865,0.0003305035,0.0005177863,0.000726738,0.00006359183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007427705,"about_ca_system_score_gemma":0.003221871,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9389777,"about_ca_topic_score_gemma":0.9967511,"domain_scores_codex":[0.9970834,0.000227231,0.000677217,0.0006017589,0.0005446566,0.0008658001],"domain_scores_gemma":[0.9986772,0.0003451811,0.0001488697,0.0006708995,0.0001185046,0.00003933481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001093721,0.00009832672,0.9426973,0.0004365185,0.00004517581,0.001427005,0.0003724162,0.00001954587,0.01044569,0.0001394921,0.0427848,0.0004399803],"study_design_scores_gemma":[0.002469125,0.0001135389,0.9763253,0.002456473,0.00001648669,0.000007058543,0.00007042754,0.000927317,0.006211673,0.0008928001,0.01025294,0.0002568527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689929,0.0005746881,0.000003162537,0.001072359,0.0002341921,0.001123949,0.00002845095,0.00002401526,0.02794623],"genre_scores_gemma":[0.9904348,0.00005516687,0.0002269972,0.006722669,0.0001438379,0.0001074713,0.00001277834,0.00003744391,0.00225881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05777334,"threshold_uncertainty_score":0.9392068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03529592364362828,"score_gpt":0.3196789620739154,"score_spread":0.2843830384302872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}