{"id":"W4384926342","doi":"10.1172/jci165370","title":"Cell-free, high-density lipoprotein–specific phospholipid efflux assay predicts incident cardiovascular disease","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Clinical Center; Department of Medicine, Georgetown University; National Institutes of Health; NHLBI Division of Intramural Research; McGill University; McGill University Health Centre; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Hjärt-Lungfonden; Karolinska Institutet; Georgetown University; George Washington University; AstraZeneca","keywords":"Phospholipid; Disease; Cholesterol; Tangier disease; High-density lipoprotein; Lipoprotein; Efflux; Reverse cholesterol transport; Cell; Chemistry; ABCA1; Medicine; Biochemistry; Internal medicine; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001273728,0.0004680781,0.0003303757,0.000625914,0.0001874289,0.0006487948,0.0003372915,0.000498663,0.001049675],"category_scores_gemma":[0.002342578,0.0002393731,0.0002105455,0.0004258038,0.0001968685,0.0002775466,0.0002934562,0.0006156954,0.0003206154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001477818,"about_ca_system_score_gemma":0.0001902796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000650094,"about_ca_topic_score_gemma":0.00104661,"domain_scores_codex":[0.99937,0.0002239403,0.0000721152,0.0001341717,0.0001490981,0.00005067961],"domain_scores_gemma":[0.9979032,0.0006344328,0.00066146,0.0002117373,0.0003766418,0.0002125425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004361316,0.0001178313,0.9919536,0.00002025939,0.0001159292,0.00001843337,0.00001711866,0.0001268212,0.004310472,0.00001682429,0.0001221607,0.002744421],"study_design_scores_gemma":[0.00004015314,0.0004967185,0.99251,0.000006521337,0.0001398864,0.0003707762,0.00003311085,0.00195164,0.004144865,0.00005179445,0.0002441764,0.00001024869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974177,0.0006288492,0.001001844,0.00003301953,0.0000127603,0.00001703616,0.0003782866,0.00003104461,0.0004795363],"genre_scores_gemma":[0.9982392,0.0001292214,0.0007527289,0.00003119982,0.00001405302,0.00001548458,0.0005816122,0.000002745698,0.0002338358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273728,"threshold_uncertainty_score":0.006736159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05347335539407461,"score_gpt":0.3127314400346384,"score_spread":0.2592580846405638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}