{"id":"W4384926617","doi":"10.1038/s43587-023-00457-3","title":"LONRF2 is a gatekeeper against protein aggregation in aging neurons","year":2023,"lang":"en","type":"letter","venue":"Nature Aging","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"","keywords":"Neurodegeneration; Protein aggregation; Protein folding; Cell biology; Neuroscience; Biology; Chemistry; Medicine; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001174467,0.0003683401,0.0002603307,0.0002030912,0.00007796061,0.00008478153,0.0003122984,0.001287756,0.00001451523],"category_scores_gemma":[0.0001569938,0.0003675153,0.0001887388,0.0002261317,0.00004981344,0.000006507753,0.0001792891,0.002151156,0.00003672955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000396429,"about_ca_system_score_gemma":0.0001150087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003989909,"about_ca_topic_score_gemma":0.00003423818,"domain_scores_codex":[0.9979835,0.0001018101,0.0002832962,0.0007984681,0.0003166183,0.0005163438],"domain_scores_gemma":[0.9991404,0.00002173608,0.0001520759,0.0005438249,0.00007160643,0.00007032213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001920444,0.00002745243,0.001631922,0.0004361564,0.0000730681,0.001331296,0.0001003549,0.00006969013,0.02287388,0.000007883795,0.9692815,0.004147582],"study_design_scores_gemma":[0.0008342954,0.00004302465,0.0008359876,0.0009858011,0.00004988681,0.00001663684,0.00004182995,0.0002374963,0.046849,0.0001519033,0.9491211,0.0008330412],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5271599,0.008843259,0.00005677654,0.4566921,0.001361188,0.001356968,0.0003207043,0.0001769488,0.004032094],"genre_scores_gemma":[0.3885777,0.0007494541,0.0001957897,0.5930079,0.005076182,0.0002281618,0.003793326,0.0002508803,0.008120568],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.1385823,"threshold_uncertainty_score":0.9998777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006396700746964985,"score_gpt":0.2491400609699819,"score_spread":0.2427433602230169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}