{"id":"W4384931169","doi":"10.3390/curroncol30070498","title":"Molecular Mechanisms of Cutaneous Immune-Related Adverse Events (irAEs) Induced by Immune Checkpoint Inhibitors","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Kaohsiung Medical University Chung-Ho Memorial Hospital; National Science and Technology Council; Kaohsiung Medical University","keywords":"Medicine; Immune system; Adverse effect; Immunology; Immune checkpoint; Cancer; Immunotherapy; Bioinformatics; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003319555,0.0006607988,0.0009931107,0.001306851,0.0001910883,0.0006349213,0.0005351048,0.0006094792,0.002768622],"category_scores_gemma":[0.0004953357,0.0001950477,0.0006602416,0.0009301977,0.0002376854,0.0006668519,0.0003793882,0.0009800742,0.000781842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003874793,"about_ca_system_score_gemma":0.0005997159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005480518,"about_ca_topic_score_gemma":0.001057736,"domain_scores_codex":[0.9998304,0.00003358069,0.00003109452,0.0000261227,0.00005857151,0.00002032241],"domain_scores_gemma":[0.9998455,0.00006601808,0.00003749573,0.000003885282,0.00003769526,0.000009334949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001520837,0.0001012167,0.0004583675,0.02896098,0.0002435474,0.0004255441,0.00006469041,0.0006158249,0.00438719,0.002913417,0.02424777,0.9374292],"study_design_scores_gemma":[0.0000814855,0.0003420041,0.003896598,0.008491491,0.0005892706,0.004812912,0.00008221275,0.0003187033,0.003213012,0.002864635,0.9752661,0.00004150556],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003902097,0.9981309,0.0001444766,0.0001860018,0.000105988,0.000009676054,0.00003248426,0.000009917047,0.0009904292],"genre_scores_gemma":[0.00208193,0.9968837,0.0001579185,0.0001812896,0.00009885343,0.00001425495,0.00004723495,0.00000125072,0.0005335882],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002768622,"threshold_uncertainty_score":0.009262025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07580870574116809,"score_gpt":0.394284003578308,"score_spread":0.3184752978371398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}