{"id":"W4384932375","doi":"10.3390/cells12141897","title":"The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Southeastern Ontario Academic Medical Organization; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mitochondrial fission; Cell biology; MFN2; DNM1L; mitochondrial fusion; Biology; Mitochondrion; MFN1; DNAJA3; Mitophagy; Cardiolipin; FIS1; Autophagy; Biochemistry; Apoptosis; Mitochondrial DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002954302,0.0002798919,0.0003891712,0.0005395868,0.0003090703,0.0006201888,0.0002819489,0.0006046956,0.001330272],"category_scores_gemma":[0.0003209261,0.0001031476,0.0003572472,0.0003189365,0.0005183823,0.0007429527,0.0004304116,0.0009949086,0.0001645305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006005175,"about_ca_system_score_gemma":0.0003884083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009089884,"about_ca_topic_score_gemma":0.001322253,"domain_scores_codex":[0.9999279,0.00001580227,0.000006441323,0.00001511428,0.00001565381,0.00001915912],"domain_scores_gemma":[0.999811,0.00004321041,0.00005487746,0.000008933731,0.00002714461,0.00005483069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008186081,0.0009176031,0.05597752,0.003494422,0.0004240509,0.008590721,0.001423165,0.003556496,0.362473,0.04604419,0.01819218,0.4907206],"study_design_scores_gemma":[0.000622161,0.002723613,0.5349661,0.001722745,0.0008018832,0.0193768,0.002868843,0.01174895,0.08148979,0.05713549,0.2863142,0.0002295892],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2913895,0.6801318,0.003214719,0.01378788,0.001101269,0.00003455286,0.0002711513,0.00007805679,0.009991127],"genre_scores_gemma":[0.7753185,0.2148841,0.001730453,0.001579596,0.001257921,0.00005909549,0.0001956547,0.00001566272,0.004959005],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001330272,"threshold_uncertainty_score":0.004450262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556907681123138,"score_gpt":0.2725524192701189,"score_spread":0.2569833424588875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}