{"id":"W4384932375","doi":"10.3390/cells12141897","title":"The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Southeastern Ontario Academic Medical Organization; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mitochondrial fission; Cell biology; MFN2; DNM1L; mitochondrial fusion; Biology; Mitochondrion; MFN1; DNAJA3; Mitophagy; Cardiolipin; FIS1; Autophagy; Biochemistry; Apoptosis; Mitochondrial DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011594,0.0002051296,0.0004541496,0.00007420705,0.0001035329,0.00002354507,0.00009926116,0.0002963571,9.980181e-7],"category_scores_gemma":[0.00009681377,0.0001330101,0.00006690591,0.0001578649,0.0001491333,0.000004710249,0.0001171448,0.0001577357,2.713692e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002562034,"about_ca_system_score_gemma":0.0001171964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005795042,"about_ca_topic_score_gemma":0.000671065,"domain_scores_codex":[0.9986982,0.0002042879,0.0004545518,0.0004097696,0.00004607253,0.0001871613],"domain_scores_gemma":[0.9992942,0.0002119144,0.0001914295,0.0002242615,0.00003339163,0.00004475343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007540485,0.0003098113,0.0009593241,0.004176547,0.0001065366,0.00001279256,0.0002740087,0.000116709,0.3784853,0.0004516914,0.0001404486,0.6142128],"study_design_scores_gemma":[0.03588921,0.00482035,0.03091371,0.05542668,0.005055942,0.0008651824,0.008013819,0.1347705,0.03354618,0.02824498,0.652327,0.01012642],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1343437,0.8614721,0.00001545428,0.0002308014,0.000485696,0.003105597,0.0002909716,0.000006302654,0.00004939267],"genre_scores_gemma":[0.01788682,0.9794818,0.0001703475,0.00001836515,0.0002955261,0.001143715,0.0003984154,0.00005704883,0.0005479224],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6521865,"threshold_uncertainty_score":0.5423996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556907681123138,"score_gpt":0.2725524192701189,"score_spread":0.2569833424588875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}