{"id":"W4384932491","doi":"10.3390/genes14071479","title":"Investigating the Genetic Background of Spastic Syndrome in North American Holstein Cattle Based on Heritability, Genome-Wide Association, and Functional Genomic Analyses","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Genome-wide association study; Biology; Candidate gene; Single-nucleotide polymorphism; Genetics; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008550945,0.0003868437,0.0003139437,0.001611718,0.000849639,0.0004788734,0.0003192422,0.0003821254,0.001650099],"category_scores_gemma":[0.0008973586,0.0002134447,0.0002490518,0.001159164,0.0003803745,0.000168163,0.0003272622,0.0002450595,0.0001409766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003463172,"about_ca_system_score_gemma":0.000312281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01928833,"about_ca_topic_score_gemma":0.02831187,"domain_scores_codex":[0.9993692,0.00018269,0.00003447073,0.0002172795,0.0001135641,0.00008293075],"domain_scores_gemma":[0.9995698,0.000176348,0.0001005302,0.00003155302,0.00004947927,0.00007219081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000366009,0.0001320677,0.9610504,0.00003517513,0.0003297666,0.002725316,0.001301911,0.0002375766,0.0260624,0.0002082134,0.0002581049,0.007292991],"study_design_scores_gemma":[0.00001127904,0.0000499515,0.9977672,0.000009506474,0.0001164081,0.0006770802,0.0002428347,0.0003598498,0.0003342826,0.00004524718,0.0003821519,0.000004121513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999114,0.0001279382,0.0002824607,0.00002111362,0.000001993943,0.000004885849,0.0001364538,0.000004648444,0.0003066252],"genre_scores_gemma":[0.9986357,0.0001831542,0.0004804004,0.00003374378,0.000005597029,0.00001312845,0.000292923,0.000005740264,0.000349645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01928833,"threshold_uncertainty_score":0.03835213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07184655557439538,"score_gpt":0.2856686404853194,"score_spread":0.213822084910924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}