{"id":"W4384934928","doi":"10.20944/preprints202307.1417.v1","title":"Phenotypic Differences among Recently Diagnosed Drug-Naïve Patients with Parkinson’s Disease with or without SNCA Polymorphisms","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; Sanofi Genzyme; Allergan; Genentech; H. Lundbeck A/S; Servier; Voyager Therapeutics; Neurocrine Biosciences; Biogen; Celgene; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Michael J. Fox Foundation for Parkinson's Research","keywords":"Single-nucleotide polymorphism; Internal medicine; SNP; Medicine; Logistic regression; Anxiety; Parkinson's disease; Drug-naïve; Disease; Geriatric Depression Scale; Oncology; Montreal Cognitive Assessment; Psychiatry; Dementia; Psychology; Drug; Genotype; Genetics; Biology; Gene; Depressive symptoms","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003585469,0.0003123322,0.000521423,0.0005404145,0.0004106945,0.000412992,0.0002005312,0.0004458799,0.001838294],"category_scores_gemma":[0.00193907,0.0001495036,0.0004074583,0.0004260586,0.0002360055,0.0003081494,0.0002849811,0.0002802013,0.0003018993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000134238,"about_ca_system_score_gemma":0.0001191895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014264,"about_ca_topic_score_gemma":0.001412374,"domain_scores_codex":[0.9996194,0.00008545052,0.00006281305,0.0001393247,0.0000526472,0.0000403283],"domain_scores_gemma":[0.9991869,0.0002877001,0.0002662737,0.00006053015,0.00005822327,0.0001404199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006462884,0.00007105719,0.9945592,0.0000151385,0.00008499891,0.00106283,0.0001428654,0.00005457296,0.001484751,0.00003366628,0.0000688505,0.001775713],"study_design_scores_gemma":[0.00001578689,0.0001718835,0.9978269,0.000003433438,0.0000207973,0.001599936,0.0000694274,0.000104488,0.0000481272,0.00003980065,0.00009572569,0.000003596311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994146,0.0001366921,0.00004259591,0.00001261374,0.00000465689,0.000005431988,0.00009505389,0.000001282386,0.0002871501],"genre_scores_gemma":[0.9994946,0.00004748741,0.00003709935,0.00002170072,0.000008887131,0.000006354478,0.0002458968,0.00000156559,0.0001364493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001838294,"threshold_uncertainty_score":0.006149709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07247389541542075,"score_gpt":0.3013858816692492,"score_spread":0.2289119862538285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}