{"id":"W4384934986","doi":"10.20944/preprints202307.1409.v1","title":"Advancing Epidemiology and Genetic Approaches for the Treatment of Spinal and Bulbar Muscular Atrophy (SBMA): Focus on Prevalence in the Indigenous Population of Western Canada","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute; Alberta Innovates; Heart and Stroke Foundation of Canada; U.S. Department of Defense","keywords":"Population; Spinal and bulbar muscular atrophy; Disease; Spinal muscular atrophy; Biology; Medicine; Bioinformatics; Androgen receptor; Genetics; Pathology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003401465,0.000628223,0.0008210188,0.003689959,0.003136413,0.0024454,0.001776638,0.0009483823,0.00779359],"category_scores_gemma":[0.009194289,0.0002435617,0.0009643747,0.004752062,0.001305462,0.0009692098,0.001678723,0.002076431,0.0008881185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.03707232,"about_ca_system_score_gemma":0.1187784,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9823279,"about_ca_topic_score_gemma":0.9845633,"domain_scores_codex":[0.9979529,0.0003425868,0.0001162634,0.0002592341,0.000879758,0.0004492872],"domain_scores_gemma":[0.9909257,0.0008245527,0.0005663021,0.0001499517,0.005773745,0.001759825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002916495,0.0002321928,0.3162927,0.003656531,0.0004597278,0.0007172822,0.003717536,0.001382261,0.002224055,0.01207811,0.1784515,0.4804965],"study_design_scores_gemma":[0.0001148286,0.0001460398,0.7154909,0.01070998,0.0009370476,0.001255051,0.008068383,0.001814537,0.0014215,0.004809367,0.2550183,0.0002139427],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1374014,0.3942004,0.01264203,0.3406385,0.004244229,0.0006656935,0.02868675,0.0007657987,0.08075514],"genre_scores_gemma":[0.4965745,0.4089207,0.02746704,0.03234261,0.003276057,0.0005123254,0.01087962,0.0004782524,0.01954888],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03707232,"threshold_uncertainty_score":0.2689797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2190011159674164,"score_gpt":0.3600901789127928,"score_spread":0.1410890629453764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}