{"id":"W4384942580","doi":"10.3791/64770","title":"A Human Cerebral Organoid Model of Neural Cell Transplantation","year":2023,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé","keywords":"Organoid; Transplantation; Induced pluripotent stem cell; Xenotransplantation; Context (archaeology); Neural stem cell; Progenitor cell; Biology; Neuroscience; Stem cell; Embryonic stem cell; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006189579,0.0009945878,0.0005731037,0.0009195699,0.0006145721,0.0007134077,0.001159199,0.0009972155,0.003042038],"category_scores_gemma":[0.000226287,0.0003061593,0.0008441999,0.0007353731,0.0006567298,0.0005259367,0.0006921567,0.001780061,0.001566855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007660624,"about_ca_system_score_gemma":0.001952495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00321458,"about_ca_topic_score_gemma":0.003771738,"domain_scores_codex":[0.9994943,0.0000739928,0.00003810839,0.0001637969,0.0001818966,0.00004782864],"domain_scores_gemma":[0.999756,0.00004623439,0.00003387565,0.00007263965,0.00004080758,0.00005046118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002866126,0.0002480851,0.0003138905,0.0002890562,0.00003571813,0.00143318,0.0001767887,0.002611605,0.9791639,0.003639178,0.001676179,0.01012575],"study_design_scores_gemma":[0.00007112413,0.001140565,0.001294426,0.0001022414,0.0001074498,0.00377036,0.0001192461,0.006238835,0.9315762,0.0008211707,0.05469905,0.00005930346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4688078,0.0109799,0.4699703,0.001030527,0.001814829,0.002127944,0.01158204,0.002846661,0.03083996],"genre_scores_gemma":[0.7313944,0.01107165,0.2275488,0.0002909098,0.00008189782,0.002776261,0.007659841,0.0002813577,0.01889498],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00321458,"threshold_uncertainty_score":0.01017666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03952250406074016,"score_gpt":0.4092958935383797,"score_spread":0.3697733894776395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}