{"id":"W4384943166","doi":"10.1101/2023.07.19.549759","title":"A mouse model of ATRX deficiency with cognitive deficits and autistic traits","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Robarts Research Institute; Canada First Research Excellence Fund","keywords":"ATRX; Neuroscience; Autism; Forebrain; Psychology; Haploinsufficiency; Epigenetics; Biology; Developmental psychology; Gene; Genetics; Central nervous system; Mutation; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003765438,0.001529925,0.0004880964,0.003210817,0.0006781714,0.0004741073,0.000770874,0.001490625,0.005418056],"category_scores_gemma":[0.0001659991,0.0005118518,0.000624041,0.0005665192,0.0009342515,0.0004359467,0.0007930147,0.001821872,0.001389363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006484567,"about_ca_system_score_gemma":0.0004026493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001199,"about_ca_topic_score_gemma":0.00207087,"domain_scores_codex":[0.9995734,0.00005019511,0.00006292,0.0001152828,0.0001296888,0.00006855757],"domain_scores_gemma":[0.9995023,0.00007256548,0.0001808565,0.00004997117,0.00003387396,0.0001604794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005258543,0.0003205868,0.0006542493,0.00006599286,0.00002989983,0.001450455,0.0001043059,0.0001717554,0.9928296,0.0009106858,0.0004405098,0.002496041],"study_design_scores_gemma":[0.000473993,0.002337078,0.01459796,0.0001214789,0.0001907883,0.009695489,0.0002875681,0.003425158,0.948945,0.001270354,0.01859282,0.00006223208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756883,0.001337679,0.009515455,0.001141506,0.0002105056,0.0002925333,0.004478893,0.001119002,0.006216143],"genre_scores_gemma":[0.922085,0.001709131,0.02322168,0.0006709516,0.00008737128,0.0007643324,0.004599037,0.0004740874,0.04638843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005418056,"threshold_uncertainty_score":0.01812524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677095636829967,"score_gpt":0.2130071361682039,"score_spread":0.1962361797999042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}