{"id":"W4385064061","doi":"10.1158/2326-6066.cir-22-0912","title":"Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; European Commission; Deutsches Krebsforschungszentrum; Swiss Cancer Research Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Cancer research; Downregulation and upregulation; Cytotoxic T cell; Biology; Tumor microenvironment; Carcinogenesis; CD8; Tumor progression; Cancer; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002523779,0.0006083826,0.0003442427,0.0005203323,0.0001618009,0.0002327181,0.000207026,0.0005002741,0.001308625],"category_scores_gemma":[0.0001022696,0.0002447438,0.0003606384,0.0001817675,0.0002908876,0.0002275138,0.0002048312,0.001331351,0.0003921765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003768805,"about_ca_system_score_gemma":0.000257428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000623588,"about_ca_topic_score_gemma":0.001033813,"domain_scores_codex":[0.9997328,0.00004880446,0.00002237625,0.00006237115,0.00006057263,0.00007302985],"domain_scores_gemma":[0.9998024,0.00001635061,0.00006291222,0.0000280281,0.00001329304,0.00007692817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003975666,0.000210965,0.0001699202,0.00004172331,0.00000562068,0.0000561411,0.00002197052,0.0000826726,0.9980489,0.00007160635,0.00005032264,0.0008425354],"study_design_scores_gemma":[0.0001756128,0.005442977,0.005796644,0.00002163343,0.00004049311,0.0005165758,0.0000498031,0.00258575,0.9827586,0.00007636567,0.002524264,0.00001119292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963377,0.0006878424,0.001344361,0.0001430379,0.00003492091,0.0000875077,0.0003621964,0.0001048757,0.0008976723],"genre_scores_gemma":[0.9947175,0.0005107985,0.002073714,0.00006840101,0.00001551505,0.000113531,0.0003450785,0.00001925701,0.002136171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308625,"threshold_uncertainty_score":0.004377782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06070083626266562,"score_gpt":0.3709813163964048,"score_spread":0.3102804801337392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}