{"id":"W4385064087","doi":"10.1186/s12964-023-01201-5","title":"GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling","year":2023,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Zhengzhou University; First Affiliated Hospital of Zhengzhou University; University of British Columbia; National Natural Science Foundation of China","keywords":"Cytotrophoblast; Human chorionic gonadotropin; Trophoblast; Placenta; Biology; Downregulation and upregulation; Gonadotropin; Endocrinology; Signal transduction; Placentation; Cell biology; Growth differentiation factor-9; Internal medicine; Transforming growth factor; Gene; Embryo; Fetus; Pregnancy; Folliculogenesis; Embryogenesis; Medicine; Genetics; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003385909,0.0002244339,0.0001738939,0.00008251345,0.0007871932,0.0001136341,0.0004261837,0.0001647769,0.00008265438],"category_scores_gemma":[0.00006078728,0.0002353545,0.00008290807,0.0001658064,0.0001143594,0.00001760023,0.0003867239,0.0001785203,0.00001459245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002653925,"about_ca_system_score_gemma":0.00004202454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003009683,"about_ca_topic_score_gemma":0.000008191694,"domain_scores_codex":[0.9985369,0.0002216779,0.0003526772,0.0003956413,0.0001816176,0.0003115002],"domain_scores_gemma":[0.9988952,0.0001042008,0.0001982844,0.0005998584,0.00006868476,0.0001337855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000259699,0.0000589527,0.001509659,0.00004436351,0.00001575377,6.465726e-7,0.0002481483,0.0009135907,0.9947386,0.00002746709,0.00187553,0.0005413516],"study_design_scores_gemma":[0.0006359383,0.00005032053,0.0005156375,0.0001468102,0.00001307375,0.000001925822,0.0007955203,0.0004753789,0.9875937,0.00008752233,0.009378837,0.0003053457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945835,0.004206165,0.0004497586,0.00006843478,0.00003908941,0.0001874119,0.00001569407,0.0001188904,0.0003310573],"genre_scores_gemma":[0.9965513,0.000203642,0.0009022802,0.0000828251,0.00009178694,0.00003989464,0.001456753,0.00004900825,0.0006224833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007503308,"threshold_uncertainty_score":0.959748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246532216798553,"score_gpt":0.2566812512445663,"score_spread":0.2442159290765807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}