{"id":"W4385064174","doi":"10.1002/bies.202300124","title":"Order out of disorder: Regulation of endonuclease activity during eukaryotic mismatch repair","year":2023,"lang":"en","type":"letter","venue":"BioEssays","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"DNA mismatch repair; Endonuclease; Biology; Base pair; DNA polymerase; DNA; Proofreading; Genetics; DNA repair; Base excision repair; AP site; DNA clamp; Cell biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002399265,0.0003020493,0.0003785702,0.0004393916,0.000451948,0.001527,0.0004419831,0.0005683429,0.001086312],"category_scores_gemma":[0.0003702489,0.0002687351,0.000167189,0.0002927101,0.0006745443,0.001024908,0.0005989099,0.0004972564,0.0005832012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001324733,"about_ca_system_score_gemma":0.0002211269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008188484,"about_ca_topic_score_gemma":0.001480206,"domain_scores_codex":[0.9996901,0.00002596798,0.00001984293,0.0001167856,0.00009010162,0.00005722676],"domain_scores_gemma":[0.9996531,0.00005272113,0.0001186187,0.00001908106,0.00006586133,0.00009065109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002251811,0.00006267017,0.004156801,0.0001822083,0.00001323811,0.0001085059,0.0002829462,0.0008383446,0.9728318,0.003343919,0.000846698,0.0171077],"study_design_scores_gemma":[0.0000948769,0.0005799946,0.2474627,0.0001652114,0.00006019423,0.001106454,0.0008605708,0.03294558,0.6491428,0.01747809,0.049971,0.0001325995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.9230409,0.04270082,0.0203002,0.001009296,0.0002471655,0.00007605437,0.001127477,0.0007220195,0.01077604],"genre_scores_gemma":[0.9906386,0.003851751,0.002410389,0.0001702837,0.0001048623,0.00003511687,0.0003974669,0.00007267037,0.002318818],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.001527,"threshold_uncertainty_score":0.009611607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02602981923082254,"score_gpt":0.268798850119736,"score_spread":0.2427690308889134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}