{"id":"W4385064174","doi":"10.1002/bies.202300124","title":"Order out of disorder: Regulation of endonuclease activity during eukaryotic mismatch repair","year":2023,"lang":"en","type":"letter","venue":"BioEssays","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"DNA mismatch repair; Endonuclease; Biology; Base pair; DNA polymerase; DNA; Proofreading; Genetics; DNA repair; Base excision repair; AP site; DNA clamp; Cell biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001754323,0.0003504422,0.0008334044,0.0002861752,0.00004342562,0.000005842378,0.0001763001,0.0007486123,0.0004141688],"category_scores_gemma":[0.0003728867,0.0003256646,0.0003445191,0.0003807536,0.0002105141,0.00004007435,0.0001440101,0.0007452988,0.00004893028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001702103,"about_ca_system_score_gemma":0.0002403991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000285174,"about_ca_topic_score_gemma":0.00005961888,"domain_scores_codex":[0.9977195,0.0001098561,0.0005429878,0.0005335583,0.0007368224,0.0003573197],"domain_scores_gemma":[0.9980607,0.0002020597,0.000480412,0.0009010836,0.000287827,0.00006790603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0009256348,0.0003497531,0.04776061,0.01555082,0.0008652926,0.0002805954,0.000786845,0.00008398551,0.1233927,0.000007908257,0.8078263,0.002169577],"study_design_scores_gemma":[0.005742272,0.001656405,0.7018269,0.003706773,0.002006624,0.00007494003,0.0001608705,0.0009675544,0.169295,0.0004175938,0.1125399,0.001605149],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9312216,0.0003081901,0.00005063803,0.062665,0.00200843,0.001168557,0.0002026716,0.0003530491,0.002021891],"genre_scores_gemma":[0.9793161,0.0001593727,0.0009910761,0.006905919,0.001684052,0.00007415322,0.0002569461,0.0002451983,0.01036723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6952863,"threshold_uncertainty_score":0.9999195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02602981923082254,"score_gpt":0.268798850119736,"score_spread":0.2427690308889134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}