{"id":"W4385064323","doi":"10.1038/s41467-023-39996-z","title":"Obesity-associated changes in molecular biology of primary breast cancer","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; University of British Columbia","funders":"National Cancer Institute; BC Cancer Agency; Vlaamse regering; Kom op tegen Kanker; Institut National Du Cancer; Deutsche Krebshilfe; Onderzoeksraad, KU Leuven; Fonds Wetenschappelijk Onderzoek; KU Leuven; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Breast Cancer Research Foundation; European Commission; Sanofi; University of Cambridge; James S. McDonnell Foundation; Cancer Research UK; Wellcome Trust","keywords":"Obesity; Breast cancer; Overweight; Estrogen receptor; Body mass index; Phenotype; Transcriptome; Biology; Cancer; Inflammation; Bioinformatics; Internal medicine; Oncology; Tumor microenvironment; Medicine; Physiology; Cancer research; Endocrinology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264057,0.0000619763,0.0002013112,0.000181898,0.00003554966,0.000002107241,0.0002471413,0.0002126889,0.00003111851],"category_scores_gemma":[0.00005625338,0.00005626184,0.00004237558,0.0007689853,0.00008409922,0.0000143239,0.0001530006,0.0005016202,0.000004235052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000133061,"about_ca_system_score_gemma":0.0001042336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006815974,"about_ca_topic_score_gemma":0.006811726,"domain_scores_codex":[0.9995331,0.00005878951,0.0001203532,0.00009325908,0.00007334603,0.0001211974],"domain_scores_gemma":[0.9990649,0.00008949172,0.00006546269,0.0006448317,0.0001026401,0.00003266164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003338443,0.0003243899,0.9206482,0.00004709725,0.0001107957,0.000004307463,0.0004749676,0.00000515587,0.06345443,0.004300443,0.002602964,0.00799389],"study_design_scores_gemma":[0.0004863822,0.00002469045,0.9901291,0.00009681828,0.00003606278,0.000002431646,0.00005927354,0.00007421736,0.0009768005,0.0001689437,0.007884887,0.00006035986],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576836,0.009740465,0.000004896314,0.02967688,0.0001206565,0.0002861578,0.0003564519,0.00008942714,0.002041515],"genre_scores_gemma":[0.993308,0.005399393,0.0001386557,0.0006261077,0.00001468774,0.0000439187,0.0003640071,0.00001048391,0.00009476678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06948096,"threshold_uncertainty_score":0.3801103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501610138794918,"score_gpt":0.3535111857910531,"score_spread":0.3284950844031039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}