{"id":"W4385064323","doi":"10.1038/s41467-023-39996-z","title":"Obesity-associated changes in molecular biology of primary breast cancer","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; University of British Columbia","funders":"National Cancer Institute; BC Cancer Agency; Vlaamse regering; Kom op tegen Kanker; Institut National Du Cancer; Deutsche Krebshilfe; Onderzoeksraad, KU Leuven; Fonds Wetenschappelijk Onderzoek; KU Leuven; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Breast Cancer Research Foundation; European Commission; Sanofi; University of Cambridge; James S. McDonnell Foundation; Cancer Research UK; Wellcome Trust","keywords":"Obesity; Breast cancer; Overweight; Estrogen receptor; Body mass index; Phenotype; Transcriptome; Biology; Cancer; Inflammation; Bioinformatics; Internal medicine; Oncology; Tumor microenvironment; Medicine; Physiology; Cancer research; Endocrinology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322555,0.0001510898,0.0002373305,0.0008251003,0.0001737501,0.0004571311,0.0001095198,0.0001486826,0.001459698],"category_scores_gemma":[0.000512559,0.0001036089,0.000176876,0.0007856297,0.0001885163,0.0001400061,0.0002350406,0.000232589,0.0003799073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001212866,"about_ca_system_score_gemma":0.0001223448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005122584,"about_ca_topic_score_gemma":0.0008404793,"domain_scores_codex":[0.9998273,0.0000331593,0.000014771,0.00005048346,0.00004099457,0.00003333769],"domain_scores_gemma":[0.9997153,0.00005694803,0.0001232513,0.00003720694,0.00003225448,0.00003502249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012277,0.00006546092,0.7039832,0.0001821256,0.0001940006,0.0003524927,0.0002326517,0.0003420774,0.2696228,0.0001452525,0.0004384099,0.02342938],"study_design_scores_gemma":[0.000002876055,0.00007215911,0.9935041,0.000004690034,0.00002634321,0.000652659,0.00006864534,0.0001193319,0.004474605,0.00008595002,0.0009854928,0.000003068504],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951969,0.002035944,0.0007056645,0.00005782156,0.000008005279,0.00001189967,0.001102106,0.00001727009,0.0008645211],"genre_scores_gemma":[0.9969679,0.0008316431,0.0004593562,0.00004650403,0.0000137028,0.00001737182,0.001228392,0.000007508971,0.0004277029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459698,"threshold_uncertainty_score":0.00488317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501610138794918,"score_gpt":0.3535111857910531,"score_spread":0.3284950844031039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}