{"id":"W4385065658","doi":"10.1002/ange.202307451","title":"A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; St Joseph's Health Care; McMaster University","funders":"Canadian Institutes of Health Research; Grand Challenges Canada; Canada Research Chairs; Canadian Allergy, Asthma and Immunology Foundation","keywords":"Eosinophilia; Sputum; Eosinophil peroxidase; Eosinophil; Chemistry; Airway; Eosinophil cationic protein; Eosinophilic; Peroxidase; Asthma; Biochemistry; Molecular biology; Immunology; Biology; Medicine; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008806087,0.0005741633,0.0003063421,0.0004962582,0.0001695106,0.0002653436,0.0003209007,0.0006462929,0.001459974],"category_scores_gemma":[0.0009911238,0.0002274689,0.0001786215,0.0001577399,0.0003266008,0.0001757796,0.0002678128,0.0005975082,0.0007145937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002476854,"about_ca_system_score_gemma":0.0002046446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001885041,"about_ca_topic_score_gemma":0.0003743737,"domain_scores_codex":[0.9994009,0.0002326973,0.00002968558,0.0001237416,0.0001691171,0.00004383639],"domain_scores_gemma":[0.9994738,0.000312478,0.0000678551,0.00002777784,0.0000765618,0.0000415335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002535896,0.00001548078,0.0002226611,0.00003111971,0.000002124793,0.00002096492,0.0000105247,0.00002551083,0.99742,0.00003513595,0.00005993328,0.002131256],"study_design_scores_gemma":[0.00002528104,0.0002429765,0.001479882,0.00001108548,0.0000112159,0.0004085663,0.00001505703,0.002574726,0.9935475,0.00004417636,0.001629299,0.00001023846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6102425,0.005708507,0.3751827,0.0007852526,0.0002538623,0.0009698091,0.001179422,0.00156972,0.004108062],"genre_scores_gemma":[0.6863647,0.001480155,0.3050735,0.000465228,0.00006416856,0.0009778773,0.0009274139,0.00005733674,0.004589644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459974,"threshold_uncertainty_score":0.004884124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04277106703877508,"score_gpt":0.2971587950158664,"score_spread":0.2543877279770913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}