{"id":"W4385069768","doi":"10.1101/2023.07.20.549870","title":"MERTK Coordinates Efferocytosis by Regulating Integrin Localization and Activation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"MERTK; Efferocytosis; Cell biology; Integrin; Signal transduction; Integrin alpha M; Biology; GAS6; Chemistry; Receptor tyrosine kinase; Receptor; Macrophage; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060927,0.0002460139,0.0002119276,0.0001637358,0.000178654,0.0005556886,0.0002018105,0.0003257689,0.001255289],"category_scores_gemma":[0.0001609423,0.0001393318,0.0001969905,0.0001162525,0.0001618829,0.0003707003,0.0002971822,0.0005443427,0.0005884013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006047033,"about_ca_system_score_gemma":0.0001580385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003088258,"about_ca_topic_score_gemma":0.000490801,"domain_scores_codex":[0.9997931,0.00002389113,0.00001417566,0.00005024859,0.0000549803,0.00006361704],"domain_scores_gemma":[0.9998779,0.00001691594,0.00004407855,0.00001095877,0.00002144978,0.00002859882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006713525,0.000009747932,0.0001483611,0.00001747676,0.000001470023,0.00003462263,0.00001076246,0.0001086609,0.9989008,0.0001095501,0.0000416619,0.0005497413],"study_design_scores_gemma":[0.00001756984,0.000120425,0.00617916,0.000008598305,0.00000809464,0.0002161544,0.00007120313,0.004202068,0.9867154,0.0001328562,0.002321407,0.000007166757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923119,0.001506567,0.004209481,0.00009864673,0.00003057385,0.00001689879,0.0001936167,0.0001103763,0.001521959],"genre_scores_gemma":[0.9965956,0.0003659582,0.001331325,0.00003539252,0.000004711371,0.00001297684,0.0001340435,0.00001375098,0.001506318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001255289,"threshold_uncertainty_score":0.004387438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01510392895629994,"score_gpt":0.2221925825974808,"score_spread":0.2070886536411809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}