{"id":"W4385069768","doi":"10.1101/2023.07.20.549870","title":"MERTK Coordinates Efferocytosis by Regulating Integrin Localization and Activation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"MERTK; Efferocytosis; Cell biology; Integrin; Signal transduction; Integrin alpha M; Biology; GAS6; Chemistry; Receptor tyrosine kinase; Receptor; Macrophage; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000560906,0.0005338874,0.0006274581,0.0003085812,0.000368264,0.0001782188,0.0003040725,0.001022227,0.00004498494],"category_scores_gemma":[0.0003747803,0.0005528303,0.0001118812,0.0004043135,0.000190385,0.0002457593,0.0005136392,0.0007082812,0.0001032665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436581,"about_ca_system_score_gemma":0.0001190156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002232394,"about_ca_topic_score_gemma":0.000001668693,"domain_scores_codex":[0.9975606,0.0003063689,0.0006286473,0.0009196951,0.0001048246,0.0004798967],"domain_scores_gemma":[0.9981964,0.0001828774,0.0005547693,0.0006969041,0.0003122759,0.00005679898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005189818,0.00006288171,0.005305782,0.0002182213,0.0002601782,7.868585e-7,0.00002130594,0.00008710865,0.9906644,0.0003147287,0.002981199,0.00003156144],"study_design_scores_gemma":[0.0007497863,0.00006092324,0.04822997,0.0006611565,0.0001213942,2.446309e-8,0.000009823047,0.0008616932,0.9438983,0.000009456491,0.004802454,0.0005950083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831066,0.003281372,0.01041824,0.0004247445,0.001188527,0.0007332517,0.0001456194,0.0006965954,0.000005080029],"genre_scores_gemma":[0.9988451,0.0003702636,0.0002306915,0.00008781083,0.00008630844,0.0001697152,0.00001961463,0.0001316985,0.00005882514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04676604,"threshold_uncertainty_score":0.9996923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01510392895629994,"score_gpt":0.2221925825974808,"score_spread":0.2070886536411809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}