{"id":"W4385075208","doi":"10.1002/mds.29524","title":"Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex <scp>4‐Related</scp> Hereditary Spastic Paraplegia","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation; University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Manton Center for Orphan Disease Research, Boston Children's Hospital; Studienstiftung des Deutschen Volkes; Intellectual and Developmental Disabilities Research Center; Astellas Pharma; Deutsche Forschungsgemeinschaft; National Institutes of Health; University of Cambridge; Deutscher Akademischer Austauschdienst; Ministero della Salute; Spastic Paraplegia Foundation; International Parkinson and Movement Disorder Society; Biogen","keywords":"Signal transducing adaptor protein; Paraplegia; Hereditary spastic paraplegia; Spastic; Neuroscience; Medicine; Chemistry; Psychology; Physical medicine and rehabilitation; Internal medicine; Spinal cord; Biochemistry; Gene; Phenotype; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003913383,0.000674658,0.0005449656,0.0005791739,0.0002769999,0.00009258271,0.0009206671,0.0002481867,0.0005597674],"category_scores_gemma":[0.001189293,0.0006627523,0.0002161454,0.002554164,0.0002628934,0.0003105675,0.000413016,0.0007368966,0.001350355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332889,"about_ca_system_score_gemma":0.00008055782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001803984,"about_ca_topic_score_gemma":0.0001982661,"domain_scores_codex":[0.9941567,0.0005328046,0.0009594104,0.001573604,0.00112993,0.001647619],"domain_scores_gemma":[0.9980827,0.0006165105,0.0002326909,0.0007132418,0.00002830054,0.0003265488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001981044,0.002588832,0.01231842,0.0002610475,0.00009337218,0.001662419,0.002652472,0.00931736,0.7316246,0.005082984,0.2312777,0.002922711],"study_design_scores_gemma":[0.01854204,0.005964282,0.2580898,0.0003697815,0.0001118324,0.00001050244,0.005581748,0.3013069,0.1610994,0.1422948,0.1039539,0.002675098],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765551,0.00003376583,0.00003170242,0.01426249,0.0007057471,0.00257545,0.0001389109,0.0008549406,0.004841906],"genre_scores_gemma":[0.9842851,0.0001424949,0.00003487209,0.01268305,0.00005815988,0.0005945284,0.00007784338,0.0001199327,0.002004045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5705252,"threshold_uncertainty_score":0.9995824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03066037513331105,"score_gpt":0.2429959781352501,"score_spread":0.2123356030019391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}