{"id":"W4385076797","doi":"10.2147/jaa.s410592","title":"Effect of Biologic Therapies on Airway Hyperresponsiveness and Allergic Response: A Systematic Literature Review","year":2023,"lang":"en","type":"review","venue":"Journal of Asthma and Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"National Institutes of Health; Covis Pharma; Teva Pharmaceutical Industries; Regeneron Pharmaceuticals; Sanofi; Genentech; AstraZeneca; Amgen","keywords":"Medicine; Asthma; Mepolizumab; Airway hyperresponsiveness; Immunology; Efalizumab; House dust mite; Benralizumab; Allergy; Allergen; Internal medicine; Eosinophil; Etanercept; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002358307,0.0005457223,0.004738746,0.0005957403,0.00006703968,0.00003067056,0.0001769866,0.0003253864,0.00002481124],"category_scores_gemma":[0.001345078,0.0002594189,0.0009425433,0.0004516504,0.0001431027,0.00005789325,0.00006581023,0.0005277778,0.000008639295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003604683,"about_ca_system_score_gemma":0.0002929257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.991027e-7,"about_ca_topic_score_gemma":3.51382e-7,"domain_scores_codex":[0.9949265,0.00279893,0.001356209,0.0002874203,0.000414058,0.0002168693],"domain_scores_gemma":[0.9952657,0.00244738,0.001485825,0.0003219863,0.000225848,0.0002532727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002242054,0.00007141236,0.000004577761,0.8184177,0.00116113,0.001445492,0.00006790667,2.57852e-7,0.00001763712,0.00001138016,0.0005967381,0.1759637],"study_design_scores_gemma":[0.0005762099,0.005273258,0.00009416962,0.6250741,0.0007738387,0.002448943,0.00002358401,3.716205e-7,0.000003044675,0.000001706414,0.365578,0.0001527221],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005957416,0.9925985,8.746977e-7,0.0001641254,0.0001859254,0.001035092,0.00002528969,0.00001416244,0.0000185525],"genre_scores_gemma":[0.0001627427,0.9987612,0.00001185224,0.0001751234,0.0002000289,0.00003957829,0.000009638828,0.00005380983,0.0005860009],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3649813,"threshold_uncertainty_score":0.9999858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174148938935595,"score_gpt":0.336637725888033,"score_spread":0.314896236498677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}