{"id":"W4385077092","doi":"10.1016/j.jtct.2023.07.015","title":"Younger Matched Unrelated Donors Confer Decreased Relapse Risk Compared to Older Sibling Donors in Older Patients with B Cell Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation","year":2023,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Takeda Oncology; Health Resources and Services Administration; MorphoSys; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Kiadis Pharma; bluebird bio; TG Therapeutics; Medac; Jazz Pharmaceuticals; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; StemCyte; Bristol-Myers Squibb; AstraZeneca; CSL Behring; BeiGene; HistoGenetics; Atara Biotherapeutics; CareDx; Actinium Pharmaceuticals; National Cancer Institute; Gilead Sciences; Sanofi; GlaxoSmithKline; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Amgen; Mallinckrodt Pharmaceuticals; Astellas Pharma US","keywords":"Medicine; Hazard ratio; Cumulative incidence; Transplantation; Internal medicine; Cohort; Sibling; Retrospective cohort study; Hematopoietic stem cell transplantation; Confidence interval; Hematopoietic cell; Graft-versus-host disease; Leukemia; Surgery; Incidence (geometry); Cohort study; Haematopoiesis; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003694021,0.0005145603,0.0006133249,0.0008190328,0.0002110118,0.00008614594,0.0001720912,0.000287587,0.0001755833],"category_scores_gemma":[0.00001081582,0.0004354926,0.0001127689,0.001288248,0.0001069595,0.0002382411,0.00001216236,0.0003719593,0.0001297245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004578522,"about_ca_system_score_gemma":0.0006573094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004891275,"about_ca_topic_score_gemma":0.0001786782,"domain_scores_codex":[0.9967843,0.0002568547,0.0006952923,0.0007753074,0.0007493273,0.0007389241],"domain_scores_gemma":[0.998301,0.0004731898,0.0001767584,0.0003400374,0.0001723518,0.0005366319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03416429,0.001732081,0.5305457,0.003383302,0.001103552,0.003146557,0.05594617,0.02057377,0.3475044,0.00005941937,0.000295758,0.001545048],"study_design_scores_gemma":[0.1350576,0.001419706,0.614027,0.001891882,0.001726486,0.000174679,0.002533544,0.01170374,0.2296612,0.00008151672,0.00005470441,0.001667926],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800082,0.000160407,0.01718547,0.0001313301,0.0001030627,0.001864904,0.000100292,0.0002143551,0.0002319233],"genre_scores_gemma":[0.9897323,0.006541927,0.0007117246,0.0004515456,0.00002666879,0.0001275661,0.001924311,0.0001297543,0.0003542155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1178431,"threshold_uncertainty_score":0.9998097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009848070875793475,"score_gpt":0.2380813251257432,"score_spread":0.2282332542499497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}