{"id":"W4385158502","doi":"10.7759/cureus.42340","title":"Early-Onset/Young-Onset Colorectal Carcinoma: A Comparative Analysis of Morphological Features and Biomarker Profile","year":2023,"lang":"en","type":"article","venue":"Cureus","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Provincial Laboratory of Public Health","funders":"","keywords":"Medicine; MSH6; Colorectal cancer; Lymphovascular invasion; Biomarker; Internal medicine; Oncology; Perineural invasion; Immunohistochemistry; Lynch syndrome; Population; MLH1; Pathology; Cancer; Biopsy; Gastroenterology; Metastasis; DNA mismatch repair; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003393243,0.000140181,0.000227877,0.001114935,0.0002423171,0.000335098,0.0001300706,0.0002030477,0.001279318],"category_scores_gemma":[0.0007638118,0.0001278814,0.0001835811,0.0007506259,0.0002135126,0.0003856726,0.0003620271,0.0001376829,0.0002002424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000142705,"about_ca_system_score_gemma":0.0001682559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008699194,"about_ca_topic_score_gemma":0.001231735,"domain_scores_codex":[0.9998174,0.00002549627,0.00002545206,0.00005088317,0.000037226,0.00004357293],"domain_scores_gemma":[0.9994177,0.0001206554,0.0002369097,0.00002522709,0.00009294971,0.0001065446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002069414,0.00002293226,0.9934418,0.00002293966,0.00001586577,0.0008640312,0.00007410452,0.00002302838,0.001824768,0.00001154452,0.00003833161,0.003453576],"study_design_scores_gemma":[0.000003177154,0.0002247489,0.9948447,0.000007040997,0.00001777291,0.003840811,0.0003385062,0.00006099873,0.0002839491,0.00001493822,0.0003597189,0.000003709478],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988437,0.0005778974,0.00009305327,0.000009800525,0.000003266039,0.000009834361,0.0001293308,0.000002096258,0.0003310693],"genre_scores_gemma":[0.9993163,0.0002477408,0.0001266223,0.000008735533,0.000007388659,0.000006237333,0.0001823153,8.665557e-7,0.000103733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279318,"threshold_uncertainty_score":0.004279792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04575329594836055,"score_gpt":0.3268760086085761,"score_spread":0.2811227126602156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}