{"id":"W4385160486","doi":"10.1002/pep2.24327","title":"Toward a broad‐spectrum peptide‐based inhibitor of small multidrug resistance efflux pumps","year":2023,"lang":"en","type":"article","venue":"Peptide Science","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Efflux; Peptide; Escherichia coli; Ethidium bromide; Peptide sequence; Biology; Biochemistry; Multiple drug resistance; Bacteria; Pseudomonas aeruginosa; Sarcosine; Chemistry; Microbiology; Antibiotics; Glycine; Amino acid; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008710685,0.0002360374,0.0002539732,0.0001911071,0.0001898158,0.00007148265,0.0009084606,0.0001107124,0.00002866731],"category_scores_gemma":[0.0007474831,0.0002270992,0.0001353261,0.001072948,0.001142684,0.00001784613,0.000294504,0.000119823,0.00009121426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005616917,"about_ca_system_score_gemma":0.0004654998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000055533,"about_ca_topic_score_gemma":0.0002213883,"domain_scores_codex":[0.9975461,0.00005592307,0.0004165824,0.0008221843,0.0004932308,0.0006659762],"domain_scores_gemma":[0.9985238,0.00005104261,0.0002201368,0.0008384394,0.0001895045,0.0001771146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009231663,0.0000439344,0.01171305,0.00009348174,0.000009559677,0.000009468178,0.0001077701,0.000175178,0.984724,0.0001764718,0.002726136,0.0001286457],"study_design_scores_gemma":[0.0005754558,0.0001411996,0.09934751,0.0001460505,0.00001147654,0.000004515798,0.0001988235,0.0008374941,0.8899232,0.0001957415,0.008247618,0.0003709455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943414,0.00008752522,0.001050339,0.0005102513,0.0003775879,0.0002647557,0.00004408222,0.00006721434,0.003256817],"genre_scores_gemma":[0.9875828,0.00005451107,0.007074881,0.0001346473,0.0001873083,0.00001251354,0.00003385475,0.00003003926,0.004889463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09480081,"threshold_uncertainty_score":0.9260837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027996199722245,"score_gpt":0.2637410200272133,"score_spread":0.2434610580299909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}