{"id":"W4385161939","doi":"10.3390/cancers15143708","title":"Analysis of the Circulating Metabolome of Patients with Cutaneous, Mucosal and Uveal Melanoma Reveals Distinct Metabolic Profiles with Implications for Response to Immunotherapy","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Princess Margaret Cancer Centre; Jewish General Hospital; University Health Network; University of Toronto; McGill University","funders":"","keywords":"Metabolome; Metabolomics; Melanoma; Kynurenine; Kynurenic acid; Cancer research; Kynurenine pathway; Biology; Sphingolipid; Medicine; Internal medicine; Immunology; Tryptophan; Bioinformatics; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707192,0.0002495412,0.000409211,0.000434575,0.0001890046,0.0004511665,0.00009316556,0.0002534281,0.000909575],"category_scores_gemma":[0.0004800199,0.0001108942,0.0003129999,0.000472143,0.00009877383,0.0001678247,0.0002442664,0.0003145234,0.000175605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001868727,"about_ca_system_score_gemma":0.0001329686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001238419,"about_ca_topic_score_gemma":0.001963344,"domain_scores_codex":[0.9998641,0.00003145407,0.00001372518,0.00004692896,0.00001819664,0.00002550836],"domain_scores_gemma":[0.9998524,0.00002804295,0.00005486183,0.00001290428,0.00002280422,0.00002897557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005010084,0.0001545389,0.8349863,0.0002036801,0.0006230223,0.0005287987,0.000223453,0.0004931892,0.1142922,0.00011506,0.001002709,0.04236694],"study_design_scores_gemma":[0.00003734175,0.0005999431,0.9896793,0.0000262596,0.0001622763,0.0008697859,0.0001984576,0.001023328,0.005625744,0.0001537241,0.001609376,0.00001449804],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946583,0.002275843,0.0007439312,0.000140042,0.00001638222,0.00002394903,0.001553387,0.00002368539,0.0005644698],"genre_scores_gemma":[0.9965196,0.0005978997,0.0008911011,0.0001538383,0.00001904548,0.00002577934,0.00138986,0.000009002265,0.000393872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238419,"threshold_uncertainty_score":0.003042817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380162576682904,"score_gpt":0.2783660863600531,"score_spread":0.2645644605932241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}