{"id":"W4385164124","doi":"10.1016/j.bcp.2023.115701","title":"Alpha-2-macroglobulin prevents platelet aggregation induced by brain-derived neurotrophic factor","year":2023,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital; Université de Montréal; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation Institut de Cardiologie de Montréal; Institut de Cardiologie de Montréal; Canada Foundation for Innovation","keywords":"Tropomyosin receptor kinase B; Brain-derived neurotrophic factor; Chemistry; Platelet; Neurotrophic factors; Platelet activation; Signal transduction; Receptor; Internal medicine; Cell biology; Biophysics; Endocrinology; Pharmacology; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009198483,0.0002119315,0.0001939457,0.0001011943,0.0001697121,0.00002995687,0.0003219991,0.000224004,0.0003656824],"category_scores_gemma":[0.0002630132,0.0002011893,0.00008352708,0.0005055057,0.000129446,0.0001340476,0.000133992,0.0003099941,0.0005183318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005281727,"about_ca_system_score_gemma":0.00004409036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004070445,"about_ca_topic_score_gemma":7.535002e-8,"domain_scores_codex":[0.9980978,0.0002982388,0.0003103048,0.0006049086,0.0002375443,0.0004512112],"domain_scores_gemma":[0.9992852,0.0002337053,0.0001303326,0.0001516611,0.00002799228,0.0001711677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008497864,0.00008402435,0.000004968019,0.00001130271,0.000007182209,0.00002716864,0.00002778773,0.000005658112,0.7907149,0.00001851968,0.208076,0.0009374588],"study_design_scores_gemma":[0.0009672316,0.0001331279,0.00009293054,0.000005281482,0.000009940769,0.00001454027,0.000001693542,0.000852935,0.9907116,0.0001368433,0.006868434,0.0002054071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934597,0.00006082169,0.00002889383,0.003879777,0.001604746,0.0004694317,0.00009815201,0.0003248077,0.00007368768],"genre_scores_gemma":[0.993091,0.00007163,0.00001544168,0.005588275,0.0003863573,0.00008596702,0.00009119839,0.00003070175,0.0006393925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2012076,"threshold_uncertainty_score":0.820426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04565304817025236,"score_gpt":0.3297226445230046,"score_spread":0.2840695963527523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}