{"id":"W4385188252","doi":"10.1007/s00125-023-05970-z","title":"Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell","year":2023,"lang":"en","type":"review","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary; Université de Montréal; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Breakthrough T1D Canada; National Institute of Diabetes and Digestive and Kidney Diseases; European Regional Development Fund; Health Sciences Centre Foundation; Alberta Diabetes Foundation; Generalitat de Catalunya; Diabetes Canada; Praespero; Wellcome Trust; Juvenile Diabetes Research Foundation United States of America; Canadian Institutes of Health Research; Genome Canada; Research Manitoba; Medical Research Council","keywords":"Autoimmunity; Beta cell; Islet; Type 1 diabetes; Immunology; BETA (programming language); Pancreatic islets; Diabetes mellitus; Biology; Immune system; Medicine; Neuroscience; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543997,0.0007401927,0.001078455,0.001944138,0.000271405,0.0009245939,0.0006340941,0.0009217722,0.003370624],"category_scores_gemma":[0.0004666563,0.0001686145,0.0003892961,0.00222883,0.0004630785,0.00125701,0.0007741226,0.001562371,0.001878461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004685011,"about_ca_system_score_gemma":0.00086908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009128203,"about_ca_topic_score_gemma":0.001264871,"domain_scores_codex":[0.9998666,0.00002876442,0.00001881114,0.0000212629,0.00004822756,0.00001623752],"domain_scores_gemma":[0.9998167,0.00007709856,0.00002985813,0.000005861975,0.00004232795,0.00002809712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000826176,0.00005737119,0.0001668732,0.0170101,0.00006703561,0.0001981296,0.00008203566,0.0002381463,0.00116689,0.00374459,0.0315384,0.9456478],"study_design_scores_gemma":[0.0000132183,0.0001073934,0.000802107,0.004971794,0.0000880217,0.001395598,0.00008775901,0.00004666347,0.0002274911,0.002585074,0.9896585,0.00001634534],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006387258,0.9989004,0.0000568919,0.0001984982,0.0001678206,0.000002323879,0.000009891753,0.00000524028,0.0005949946],"genre_scores_gemma":[0.0003889338,0.9989325,0.00007763351,0.0001495915,0.0001372716,0.00000278012,0.00001439313,7.585913e-7,0.0002961368],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003370624,"threshold_uncertainty_score":0.01127583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07347933060231429,"score_gpt":0.3615829046075341,"score_spread":0.2881035740052198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}