{"id":"W4385189274","doi":"10.1021/acs.jmedchem.3c00884","title":"Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; H2020 Health; Fonds Unique Interministériel; Agence Nationale de la Recherche; Eurostars; Bpifrance; Fondation Jérôme Lejeune; Horizon 2020 Framework Programme; Deutsches Krebsforschungszentrum","keywords":"DYRK1A; Natural product; Kinase; Phosphorylation; Chemistry; Cyclin-dependent kinase 1; Biochemistry; IC50; Enzyme; Protein-Tyrosine Kinases; Tyrosine kinase; Residue (chemistry); Stereochemistry; Biology; In vitro; Signal transduction; Gene; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006378186,0.0002777692,0.0001902411,0.0001509278,0.00009102355,0.0001445767,0.0001572035,0.0001402891,0.0008708448],"category_scores_gemma":[0.00005639904,0.00008264109,0.0001501946,0.00009619043,0.0001011402,0.0001640266,0.0001633281,0.0003093707,0.0002831281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001980429,"about_ca_system_score_gemma":0.0001272381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000309887,"about_ca_topic_score_gemma":0.001085375,"domain_scores_codex":[0.9999694,0.000005198536,0.000003261747,0.000006286067,0.00000819016,0.000007649803],"domain_scores_gemma":[0.9999739,0.000002187339,0.00001118212,0.000001639695,0.000003220363,0.000007883373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003670209,0.00006342042,0.0005469545,0.0001825811,0.00002025525,0.0001233517,0.00001935262,0.0005582155,0.983065,0.0001988912,0.0001902385,0.01466466],"study_design_scores_gemma":[0.0001630865,0.003504019,0.008290733,0.00002460503,0.00007387688,0.001053274,0.00004429598,0.001194694,0.9604777,0.0001111821,0.02503406,0.00002851817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711224,0.01562934,0.005667572,0.0001518623,0.00005261724,0.0001418287,0.0006258987,0.000179787,0.006428604],"genre_scores_gemma":[0.9813994,0.007773401,0.005226322,0.0001896358,0.00001857938,0.00008659537,0.0009737103,0.00001657225,0.004315865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008708448,"threshold_uncertainty_score":0.002913296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006953644748059586,"score_gpt":0.2408873986309239,"score_spread":0.2339337538828643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}