{"id":"W4385198333","doi":"10.1099/acmi.0.000675.v1","title":"Deciphering the interaction surface between the West Nile virus NS3 and NS5 proteins","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"NS3; Flavivirus; Virology; Dengue virus; Zika virus; Dengue fever; Japanese encephalitis; Flaviviridae; In silico; Biology; Replicon; Viral replication; Virus; West Nile virus; Encephalitis; Hepatitis C virus; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009099535,0.0004040587,0.0002995061,0.000190133,0.0002422497,0.0002924694,0.000243469,0.0003392939,0.001678621],"category_scores_gemma":[0.0001819012,0.0001317336,0.0004296623,0.0001191315,0.0001300869,0.0004712355,0.0002355179,0.000317918,0.0003580591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003107616,"about_ca_system_score_gemma":0.0001802521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002310207,"about_ca_topic_score_gemma":0.001796593,"domain_scores_codex":[0.9999567,0.000007976633,0.000001801723,0.00000933143,0.00001298165,0.00001115017],"domain_scores_gemma":[0.9999713,0.00001368399,0.00000493105,0.000001980169,0.000003678967,0.000004460287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005840209,0.0001630831,0.01233485,0.0003299641,0.0001392024,0.0007185559,0.0001748581,0.06627139,0.9043195,0.003097811,0.0006814557,0.01118536],"study_design_scores_gemma":[0.00002958162,0.000219563,0.01235337,0.00002158468,0.00009050086,0.0002383252,0.000247941,0.7579565,0.2242422,0.002235407,0.002337588,0.00002730155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868178,0.001012873,0.01008538,0.0001241981,0.00001477939,0.000009389077,0.000232772,0.0000771451,0.001625606],"genre_scores_gemma":[0.9947346,0.0006043854,0.003757947,0.00002178489,0.000002761876,0.000006166226,0.0004145037,0.00001415094,0.0004437782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002310207,"threshold_uncertainty_score":0.005615532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04525102574387168,"score_gpt":0.3184263850801387,"score_spread":0.273175359336267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}