{"id":"W4385212651","doi":"10.1101/2023.07.21.23293014","title":"A Parkinson’s disease genetic risk score associates with blood DNAm on chromosome 17","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pacific Centre for Reproductive Medicine; University of British Columbia","funders":"Canadian Institutes of Health Research; Agence Nationale de Sécurité du Médicament et des Produits de Santé; Bundesministerium für Bildung und Forschung; Agence Nationale de la Recherche; BC Children's Hospital","keywords":"dNaM; Genome-wide association study; Biology; Mendelian randomization; CpG site; Genetics; Genetic association; DNA methylation; Genotype; Gene; Single-nucleotide polymorphism; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00097374,0.0006002935,0.0005147245,0.001551303,0.0003999433,0.0005570286,0.000436401,0.000539383,0.004780319],"category_scores_gemma":[0.003287752,0.0002377862,0.001262558,0.001655415,0.0003360288,0.0001728776,0.000537972,0.0005972513,0.0002530483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716056,"about_ca_system_score_gemma":0.0003197838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004812508,"about_ca_topic_score_gemma":0.003905814,"domain_scores_codex":[0.9991342,0.0002792529,0.00006813236,0.0002984059,0.0001360174,0.0000840046],"domain_scores_gemma":[0.997376,0.001199261,0.0008158736,0.0002244592,0.0001799519,0.0002044633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001520694,0.00003178099,0.9732965,0.0001129816,0.0023865,0.0005679792,0.00007817568,0.0004648561,0.01316695,0.0001586044,0.0004702099,0.007744647],"study_design_scores_gemma":[0.0001276072,0.0002527177,0.9897692,0.00004460171,0.002202193,0.001070356,0.00008394927,0.001904564,0.003027378,0.0004626177,0.001038248,0.00001664247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941164,0.001367942,0.002177975,0.0002145934,0.0000417115,0.00001161568,0.001435974,0.00008060109,0.000553209],"genre_scores_gemma":[0.9979817,0.0001739754,0.0009953144,0.00005487304,0.00002658601,0.00001040963,0.0005209831,0.00001712622,0.000219155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004812508,"threshold_uncertainty_score":0.01599175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864543053642343,"score_gpt":0.2495282753293664,"score_spread":0.230882844792943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}