{"id":"W4385212779","doi":"10.3390/cancers15143706","title":"Predictors of Response to Hydroxyurea and Switch to Ruxolitinib in HU-Resistant Polycythaemia VERA Patients: A Real-World PV-NET Study","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Grifols; AOP Orphan; Swedish Orphan Biovitrum; Pfizer; Ministero della Salute; Sierra Oncology; Incyte; Alexion Pharmaceuticals; Gilead Sciences; Sanofi; Celgene; AstraZeneca; Amgen; GlaxoSmithKline","keywords":"Polycythaemia; Ruxolitinib; Polycythemia vera; Medicine; Internal medicine; Myelofibrosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001258341,0.0003089802,0.0005364732,0.0004919345,0.0002431626,0.0009555389,0.000394683,0.0005333007,0.0007356075],"category_scores_gemma":[0.003067319,0.000241619,0.0005665784,0.0008352826,0.0003090969,0.0005948092,0.000449517,0.000538684,0.0001507279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003897277,"about_ca_system_score_gemma":0.0001832797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101731,"about_ca_topic_score_gemma":0.001268593,"domain_scores_codex":[0.9990544,0.00050106,0.0001004373,0.0001707806,0.00009665193,0.00007670723],"domain_scores_gemma":[0.9966373,0.001125509,0.001394718,0.0002123571,0.0001840366,0.0004460775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001009133,0.0001283613,0.9962017,0.00002100303,0.0001614799,0.0001456894,0.00004085405,0.0002713106,0.000155085,0.00001267454,0.0001036505,0.00174906],"study_design_scores_gemma":[0.0001708246,0.000697867,0.9939662,0.00001313442,0.000139665,0.0007112489,0.0001845951,0.003648355,0.0001102685,0.00004016012,0.0003026943,0.00001500256],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995085,0.0001301559,0.00005030893,0.0000199446,0.00000316294,0.000007061893,0.0001991648,0.000001723979,0.0000799246],"genre_scores_gemma":[0.9995475,0.00004323715,0.0000454177,0.00001136291,0.000009412601,0.000005041553,0.0003140538,9.95021e-7,0.00002290291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258341,"threshold_uncertainty_score":0.006654859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744814401239356,"score_gpt":0.3075690887937115,"score_spread":0.2901209447813179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}