{"id":"W4385224975","doi":"10.26434/chemrxiv-2023-klj7x-v2","title":"Nitrene C–H Bond Insertion Approach to Carbazolones and Indolones. Formal Total Synthesis of (–)-Methyl N-Decarbomethoxychanofruticosinate, (–)-Aspidospermidine and (+)-Kopsihainanine A","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; York University; City University of New York; National Science Foundation","keywords":"Nitrene; Regioselectivity; Chemistry; Aryl; Cyclohexanone; Moiety; Azide; Stereochemistry; Medicinal chemistry; Catalysis; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163042,0.0005080175,0.0002100825,0.0001398848,0.000147168,0.0001474074,0.0003856255,0.0002397902,0.001885417],"category_scores_gemma":[0.000106866,0.0001243907,0.0001783582,0.0001368962,0.0001837457,0.000248738,0.0004457719,0.0004200415,0.0007423451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124963,"about_ca_system_score_gemma":0.0004051049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041437,"about_ca_topic_score_gemma":0.002079792,"domain_scores_codex":[0.9999136,0.00001174503,0.00000629648,0.00001763034,0.00001681195,0.00003397022],"domain_scores_gemma":[0.9999543,0.000004363744,0.00001179278,0.000008152827,0.000009538185,0.00001174523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002210236,0.0001131956,0.0002646702,0.0004700893,0.00003201234,0.0005204381,0.0001277013,0.0009184935,0.9770579,0.003081995,0.0007167151,0.01647576],"study_design_scores_gemma":[0.0001069507,0.001391615,0.001292488,0.00003402639,0.00003702833,0.0008942877,0.00006128968,0.001782888,0.95772,0.0004397837,0.03619973,0.0000398971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9148712,0.006479536,0.03763418,0.00034246,0.0002483189,0.0003459177,0.0008811491,0.000554778,0.03864237],"genre_scores_gemma":[0.9813558,0.002688406,0.009569574,0.00007846698,0.00002421809,0.0001124525,0.0004697603,0.00003275614,0.005668609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885417,"threshold_uncertainty_score":0.006307364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03266864784679588,"score_gpt":0.2570051770217095,"score_spread":0.2243365291749136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}