{"id":"W4385230232","doi":"10.7554/elife.88206","title":"Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Structural Genomics Consortium; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; LouLou Foundation; Wellcome Trust; Francis Crick Institute; National Institutes of Health; Cancer Research UK; National Institute of Neurological Disorders and Stroke; Medical Research Council; Wellcome","keywords":"Kinase; Threonine; Serine; Hippocampal formation; Cell biology; Protein kinase A; Protein-Serine-Threonine Kinases; DYRK1A; Biology; Chemistry; Biochemistry; Phosphorylation; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002312118,0.0005208461,0.0003042493,0.0002714808,0.000190783,0.000309726,0.0004057752,0.0002854793,0.000862789],"category_scores_gemma":[0.0002103184,0.0001690952,0.0003729835,0.0001509841,0.0001909089,0.0002168738,0.000178558,0.0004725408,0.0005306213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006690284,"about_ca_system_score_gemma":0.0004548394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000757986,"about_ca_topic_score_gemma":0.001618098,"domain_scores_codex":[0.9998943,0.00001085062,0.00001176459,0.00002335658,0.00003513978,0.00002461356],"domain_scores_gemma":[0.999896,0.00001547909,0.00002582477,0.000009559247,0.00001643889,0.00003659932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000829059,0.00004641246,0.0003871305,0.00008425798,0.00001376689,0.0001003164,0.00001186303,0.0002562207,0.9932337,0.0003172409,0.000114289,0.005351896],"study_design_scores_gemma":[0.00004918153,0.0005607145,0.001874416,0.00001170745,0.00004497532,0.0005675968,0.000009848224,0.001230469,0.983316,0.00005516423,0.01227109,0.000008780486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9282139,0.02136049,0.04134782,0.0004778041,0.00009882989,0.0004992475,0.001452953,0.0001827736,0.006366267],"genre_scores_gemma":[0.9649594,0.006585514,0.02150773,0.0002145311,0.00002716336,0.0001215948,0.002862912,0.00003660023,0.003684572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000862789,"threshold_uncertainty_score":0.004854202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007288025729619854,"score_gpt":0.2150968562521448,"score_spread":0.2078088305225249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}