{"id":"W4385230320","doi":"10.26508/lsa.202302101","title":"Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; UK Research and Innovation; National Science Foundation","keywords":"Chromatin; Chromatin immunoprecipitation; Biology; Chromosome; Genome; Chromosome conformation capture; Polycomb-group proteins; Immunoprecipitation; Genetics; Cell biology; DNA; Gene; Enhancer; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988678,0.00007259192,0.00008237206,0.00002742427,0.0001211415,0.00002918744,0.0002451394,0.00003511207,0.000009072289],"category_scores_gemma":[0.00008953713,0.00006353172,0.00002361041,0.0003726005,0.000679273,0.00001082697,0.00009620656,0.00003045631,0.00001564906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006220611,"about_ca_system_score_gemma":0.0001271054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001951547,"about_ca_topic_score_gemma":0.00001470576,"domain_scores_codex":[0.9991998,0.00001123952,0.0001263001,0.000291082,0.000165843,0.0002057158],"domain_scores_gemma":[0.9995028,0.00000899978,0.0000627579,0.000275578,0.00005468904,0.00009519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007633655,0.00001310202,0.007349656,0.00001151972,0.000006536061,6.288581e-7,0.00008485733,0.00003296627,0.9898779,0.001087992,0.0005733217,0.0009538599],"study_design_scores_gemma":[0.0005690556,0.0002092763,0.3284093,0.00005173179,0.00001449072,0.000007730267,0.0007316358,0.002732962,0.6589902,0.0002966486,0.007659923,0.0003270472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980371,0.0006677205,0.0001368957,0.0005073615,0.00009396922,0.0000855105,0.0000189701,0.00001275784,0.0004397023],"genre_scores_gemma":[0.9981855,0.0004431645,0.0003802854,0.0001451508,0.00005510616,0.00001459534,0.000009515521,0.000006188657,0.000760492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3308877,"threshold_uncertainty_score":0.2590748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398981526107763,"score_gpt":0.2883554201959317,"score_spread":0.2743656049348541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}