{"id":"W4385230320","doi":"10.26508/lsa.202302101","title":"Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; UK Research and Innovation; National Science Foundation","keywords":"Chromatin; Chromatin immunoprecipitation; Biology; Chromosome; Genome; Chromosome conformation capture; Polycomb-group proteins; Immunoprecipitation; Genetics; Cell biology; DNA; Gene; Enhancer; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008083056,0.0002186215,0.0001443741,0.0001601762,0.0001369209,0.0002857042,0.0002303637,0.0002015819,0.001265847],"category_scores_gemma":[0.00009197328,0.0001695577,0.0001615677,0.0001024489,0.0003340317,0.0001673782,0.000299945,0.0005632804,0.000351164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000414903,"about_ca_system_score_gemma":0.0002494619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001459255,"about_ca_topic_score_gemma":0.003308852,"domain_scores_codex":[0.9998952,0.00001477951,0.000008987158,0.00002523077,0.00003143502,0.00002430774],"domain_scores_gemma":[0.9998822,0.00002609779,0.00003800372,0.00001807367,0.000007436557,0.000028163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001373621,0.000004113572,0.00006498067,0.000007165041,0.000001386337,0.00001019357,0.000005224105,0.00002669636,0.9996135,0.00004411584,0.000006250264,0.0002026493],"study_design_scores_gemma":[0.000003586914,0.0000308292,0.001393582,0.000001300919,0.000002434894,0.00003659804,0.000008359144,0.00026661,0.9974658,0.00001603357,0.0007736059,0.000001250924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927348,0.0009020394,0.004486619,0.0001565816,0.00002039438,0.00002141169,0.0001796688,0.00007626004,0.001422269],"genre_scores_gemma":[0.993867,0.0003932287,0.001763077,0.00005680981,0.000004433152,0.0000193043,0.000284178,0.00002334946,0.003588548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459255,"threshold_uncertainty_score":0.004234731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398981526107763,"score_gpt":0.2883554201959317,"score_spread":0.2743656049348541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}