{"id":"W4385231164","doi":"10.1001/jamanetworkopen.2023.25332","title":"Association of Circulating Tumor DNA Testing Before Tissue Diagnosis With Time to Treatment Among Patients With Suspected Advanced Lung Cancer","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Merck Canada; Lung Health Foundation; Princess Margaret Cancer Foundation","keywords":"Medicine; Lung cancer; Cohort; Internal medicine; Liquid biopsy; Oncology; Biopsy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001432344,0.0002044127,0.0004689157,0.0001776159,0.0002005182,0.0004149835,0.000288703,0.0005231128,0.0008069624],"category_scores_gemma":[0.004234042,0.000200715,0.0003594209,0.0002979991,0.0002392535,0.000296118,0.0001932609,0.0005502494,0.0001130436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004753133,"about_ca_system_score_gemma":0.0007327903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002757793,"about_ca_topic_score_gemma":0.005225787,"domain_scores_codex":[0.9992943,0.0002834917,0.000055493,0.0001672542,0.0001177863,0.00008167489],"domain_scores_gemma":[0.9971728,0.001015613,0.001056977,0.0001628728,0.0001679145,0.0004236454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03306652,0.0009178332,0.9491928,0.00008936836,0.0002634522,0.00005016186,0.00007899181,0.0003638174,0.001825118,0.00003278017,0.0003674019,0.01375187],"study_design_scores_gemma":[0.003234937,0.01878962,0.9748275,0.00003144343,0.0003196762,0.0001509852,0.00006821805,0.001438798,0.000550524,0.00005303143,0.0005206586,0.00001460622],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992369,0.000333802,0.00006164438,0.00004226481,0.00001050869,0.00003488649,0.00009909634,0.000002738667,0.0001782059],"genre_scores_gemma":[0.9993911,0.00008976938,0.0001173212,0.00005474685,0.00001493582,0.00003077635,0.000198386,8.778383e-7,0.0001020825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757793,"threshold_uncertainty_score":0.007575035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00608040904331473,"score_gpt":0.2438891838970989,"score_spread":0.2378087748537842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}