{"id":"W4385231164","doi":"10.1001/jamanetworkopen.2023.25332","title":"Association of Circulating Tumor DNA Testing Before Tissue Diagnosis With Time to Treatment Among Patients With Suspected Advanced Lung Cancer","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Merck Canada; Lung Health Foundation; Princess Margaret Cancer Foundation","keywords":"Medicine; Lung cancer; Cohort; Internal medicine; Liquid biopsy; Oncology; Biopsy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417285,0.0001701147,0.0002423279,0.00002925533,0.0001130979,0.00007747301,0.0001873867,0.00006693848,0.00004348166],"category_scores_gemma":[0.0001893449,0.0001409546,0.00002515694,0.0004703098,0.000016415,0.00001232294,0.0001882962,0.00004669807,0.000006925327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020643,"about_ca_system_score_gemma":0.0001292446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005989408,"about_ca_topic_score_gemma":0.002055238,"domain_scores_codex":[0.9989159,0.00003680884,0.0002129882,0.0003451482,0.0001559166,0.0003332417],"domain_scores_gemma":[0.9990276,0.0001042125,0.0002814318,0.0002371028,0.0002566974,0.00009298174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001685044,0.00005148147,0.9347298,0.00001256236,0.0001843235,0.000005785548,0.00009951132,0.04793441,0.001192914,0.000001920041,0.003401371,0.0122174],"study_design_scores_gemma":[0.00201962,0.001294872,0.9860846,0.0003047448,0.0001114758,4.825587e-7,0.00002314085,0.001337258,0.00515558,0.000007057539,0.003407853,0.000253329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997712,0.00007762906,0.00002210407,0.0002065075,0.00005546058,0.001107673,0.0001272927,0.00001861984,0.000672695],"genre_scores_gemma":[0.9962417,0.00003175869,0.001342938,0.0001295895,0.0002985892,0.0005298043,0.0004416687,0.00004922093,0.0009347346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05135477,"threshold_uncertainty_score":0.5747961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00608040904331473,"score_gpt":0.2438891838970989,"score_spread":0.2378087748537842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}