{"id":"W4385234821","doi":"10.1016/j.micpath.2023.106270","title":"Streptococcus uberis induced expressions of pro-inflammatory IL-6, TNF-α, and IFN-γ in bovine mammary epithelial cells associated with inhibited autophagy and autophagy flux formation","year":2023,"lang":"en","type":"article","venue":"Microbial Pathogenesis","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"High-end Foreign Experts Recruitment Plan of China; National Natural Science Foundation of China","keywords":"Autophagy; Streptococcus uberis; ATG5; Downregulation and upregulation; Biology; Microbiology; Tumor necrosis factor alpha; Immunology; Apoptosis; Streptococcus; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000328101,0.0003102454,0.000557736,0.0004598232,0.0001166138,0.00002843069,0.0001006246,0.0002670225,0.00005207588],"category_scores_gemma":[0.00007562579,0.0002468675,0.0000835258,0.000676977,0.0001091725,0.0002540304,0.0001267641,0.0001801603,0.00001148455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007670886,"about_ca_system_score_gemma":0.0002023023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003722675,"about_ca_topic_score_gemma":0.00004255671,"domain_scores_codex":[0.9981888,0.0001628641,0.0005800381,0.0004235341,0.0002457542,0.0003989957],"domain_scores_gemma":[0.9989928,0.0000974188,0.0002677123,0.0003266185,0.0001238083,0.0001916262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004190085,0.0002052913,0.002317274,0.0002154213,0.00008876526,0.0002600955,0.001103016,0.000009125166,0.9864731,0.00001186376,0.0002388146,0.008658172],"study_design_scores_gemma":[0.003606621,0.0003508488,0.2739939,0.0003588386,0.00009294001,0.00002025391,0.0001457504,0.0004620925,0.7205895,0.00003306517,0.000122549,0.0002236798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978896,0.0001764885,0.00004037308,0.0001148617,0.00008798381,0.001102478,0.0003441027,0.0001945969,0.00004947663],"genre_scores_gemma":[0.9986242,0.0001191892,0.0001851822,0.0001288126,0.00006892002,0.0001069701,0.0003036688,0.00005447775,0.0004085557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2716766,"threshold_uncertainty_score":0.9999983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359130801321286,"score_gpt":0.2379308244267646,"score_spread":0.2243395164135517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}