{"id":"W4385239882","doi":"10.7554/elife.87894.1","title":"Identifying metabolic features of colorectal cancer liability using Mendelian randomization","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Chonnam National University Hwasun Hospital; Biobanco Vasco; Junta de Castilla y León; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; School of Public Health, Imperial College London; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; Imperial College London; Generalitat de Catalunya; Wereld Kanker Onderzoek Fonds; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; University of Cambridge; ZonMw; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Wellcome Trust; Cancer Research UK; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Umeå Universitet; Centres de Recerca de Catalunya; UK Research and Innovation; Bundesministerium für Bildung und Forschung; University of South Florida; Swedish Cancer Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Univerzita Karlova v Praze; Pelotonia; Moffitt Cancer Center; World Cancer Research Fund International; Johns Hopkins University; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; Emory University; Florida Department of Health; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Internal medicine; Polyunsaturated fatty acid; Oncology; Medicine; Cancer; Biology; Endocrinology; Fatty acid; Genetics; Bioinformatics; Genotype; Gene; Genetic variants; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02709498,0.001082786,0.001288261,0.002075627,0.0004602662,0.000911115,0.001101981,0.001110569,0.004133348],"category_scores_gemma":[0.05250697,0.0005189088,0.002032432,0.00138365,0.001455746,0.000874536,0.000981746,0.0008226524,0.0002931975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005033864,"about_ca_system_score_gemma":0.0007999548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002930216,"about_ca_topic_score_gemma":0.002157421,"domain_scores_codex":[0.9575799,0.03452026,0.0009635557,0.004287813,0.00196754,0.0006809247],"domain_scores_gemma":[0.9689205,0.0221472,0.003360387,0.004961577,0.0003858437,0.0002243611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.02037866,0.0009097206,0.6658075,0.0008303846,0.01418463,0.006558608,0.001746944,0.03059646,0.02966103,0.05820825,0.003873825,0.1672439],"study_design_scores_gemma":[0.003063333,0.007865406,0.4454129,0.0001992598,0.005526636,0.008513551,0.0004584799,0.4421962,0.01028501,0.06671336,0.009464155,0.0003017454],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7253643,0.0006793263,0.26811,0.0005596877,0.0001236552,0.0009143846,0.001213733,0.000707629,0.002327177],"genre_scores_gemma":[0.9372653,0.0001386532,0.06058213,0.0001204283,0.00003597322,0.000622793,0.0003500903,0.00006276965,0.0008217741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02709498,"threshold_uncertainty_score":0.1432937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03311918080888251,"score_gpt":0.3258976543533843,"score_spread":0.2927784735445018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}