{"id":"W4385248076","doi":"10.1016/j.biopha.2023.115187","title":"Epigenetic regulation of temozolomide resistance in human cancers with an emphasis on brain tumors: Function of non-coding RNAs","year":2023,"lang":"en","type":"review","venue":"Biomedicine & Pharmacotherapy","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Temozolomide; microRNA; Drug resistance; Epigenetics; Brain tumor; Context (archaeology); Cancer; Brain cancer; Biology; Bioinformatics; Glioma; Medicine; Cancer research; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476394,0.0001665833,0.0002048492,0.0002479455,0.0001290005,0.0004148663,0.0001371212,0.0001783538,0.001003843],"category_scores_gemma":[0.0001607332,0.00007706949,0.000192748,0.0002673005,0.0002215982,0.0002705573,0.00020974,0.0004001496,0.0001867145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004663099,"about_ca_system_score_gemma":0.0003204238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000692227,"about_ca_topic_score_gemma":0.00130637,"domain_scores_codex":[0.9999318,0.00001423079,0.000005550592,0.00001727828,0.0000206152,0.00001041911],"domain_scores_gemma":[0.9999539,0.000009510622,0.00001580226,0.000002609071,0.00001311861,0.000005062627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003637054,0.00004313833,0.005606552,0.003392787,0.0001848117,0.001298012,0.0005314693,0.00108852,0.626198,0.01557074,0.01286051,0.3328618],"study_design_scores_gemma":[0.00005805012,0.0004376409,0.06469554,0.0004841699,0.0003433648,0.005079559,0.0003568525,0.002345628,0.2837051,0.004910846,0.6375128,0.00007033067],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1848745,0.76823,0.01781638,0.004913418,0.001058053,0.00007191026,0.001300344,0.0003761376,0.02135929],"genre_scores_gemma":[0.5695382,0.4077629,0.005135691,0.001321042,0.0003591623,0.00007149735,0.001135248,0.00008093008,0.01459528],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001003843,"threshold_uncertainty_score":0.003383398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03535166169713501,"score_gpt":0.3678705169867063,"score_spread":0.3325188552895713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}